An old culprit but a new story: bisphenol A and "NextGen" bisphenols.
An old culprit but a new story: bisphenol A and "NextGen" bisphenols.
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DOI：
10.1016/j.fertnstert.2016.07.1114
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发表时间：
2016-09-15
影响因子：
6.7
通讯作者：
Hunt PA
中科院分区：
文献类型：
--
作者：
Sartain CV;Hunt PA
发育事件影响成人健康和疾病的概念是由于认识到孕产妇营养不良与成人冠心病之间的联系而引发的。从那时起，一个新的领域——健康和疾病的发育起源——出现了，人们的注意力集中在一系列发育扰动的影响上。接触内分泌干扰化学物质一直受到人们的特别关注，而普遍存在的环境污染物双酚 A (BPA) 已成为内分泌干扰化学物质的典型代表。近二十年来，双酚 A 一直是人们深入研究的主题，数百项实验、流行病学和临床研究都描述了接触效应。从生殖健康的角度来看，这些发现尤其重要，因为它们表明两性的卵巢、睾丸和生殖道都是 BPA 作用的目标。这些调查结果及其引起的媒体和监管机构的关注引起了公众越来越多的关注，并导致一些国家立法禁止双酚 A。随后推出的不含 BPA 的产品虽然是一项高超的营销策略，但实际上只是 BPA 故事新的复杂篇章的开始。在这篇综述中，我们试图总结我们对 BPA 生殖影响的了解，阐述为什么研究这种化学物质对人类的影响不再充分的原因，并概述不断增长的下一代双酚对临床医生、研究人员、联邦机构和公众带来的挑战。
The concept that developmental events shape adult health and disease was sparked by the recognition of a link between maternal undernutrition and coronary disease in adults. From that beginning, a new field—the developmental origins of health and disease—emerged, and attention has focused on the effects of a wide array of developmental perturbations. Exposure to endocrine-disrupting chemicals has been of particular interest, and a ubiquitous environmental contaminant bisphenol A (BPA) has become the endocrine-disrupting chemical poster child. Bisphenol A has been the subject of intense investigation for nearly two decades, and exposure effects have been described in hundreds of experimental, epidemiological, and clinical studies. From the standpoint of reproductive health, the findings are particularly important, as they suggest that the ovary, testis, and reproductive tract in both sexes are targets of BPA action. The findings and the media and regulatory attention garnered by them have generated increasing public concern and resulted in legislative bans on BPA in some countries. The subsequent introduction of BPA-free products, although a masterful marketing strategy, is in reality only the beginning of a new and complex chapter of the BPA story. In this review we attempt to summarize what we have learned about the reproductive effects of BPA, present the reasons why studying the effects of this chemical in humans is no longer sufficient, and outline the challenges that the growing array of next generation bisphenols represents to clinicians, researchers, federal agencies, and the general public.