Creatine and β-hydroxy-β-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program
Creatine and β-hydroxy-β-methylbutyrate (HMB) additively increase lean body mass and muscle strength during a weight-training program
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DOI：
10.1016/s0899-9007(01)00540-8
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发表时间：
2001-07-01
期刊：
影响因子：
4.4
通讯作者：
Nissen, S
中科院分区：
文献类型：
--
作者：
Jówko, E;Ostaszewski, P;Nissen, S
我们研究了肌酸(CR)和β-羟基-β-甲基丁酸酯(HMB)是否通过相似或不同的机制在递进式阻力运动训练中增加瘦体重(LBM)和力量。在这项双盲的3wk研究中，受试者(n=40)被随机分为安慰剂组(PL，n=10)、CR(20.0g CR/d，7d，然后再10.0g CR/d，14d；n=11)、HMB(3.0g，HMB/d；n=9)或CR-and-HMB(CR/HMB；n=10)治疗组。在3wk以上，所有受试者都获得了LBM，并通过生物电阻抗分析进行了评估。与安慰剂组相比，CR组、HMB组和CR/HMB组分别增加了0.92、0.39和1.54 kg LBM，补充CR效果显著(主效P=0.05)，补充HMB有趋势(主效P=0.08)。这些效应是相加的，因为CR和HMB之间没有交互作用(CR×HMB主效应，P=0.73)。在所有运动中，补充HMB、CR和CR/HMB的累积力量分别比安慰剂组增加了37.5、39.1和51.9公斤。补充HMB可明显抑制运动性血清肌酸磷酸激酶的升高(主效应P=0.01)。然而。补铬可拮抗HMB对血清肌酸磷酸激酶的影响(CR×HMB交互作用P=0.04)。补充CR对尿尿素氮和血浆尿素没有影响，但补充HMB后两者均降低(HMB效应P<；0.05)，提示有节氮作用。综上所述，CR和HMB可以增加LBM和强度。而且这些影响是相加的。虽然不是决定性的，但这些结果表明泰国的CR和HMB的作用机制不同。(C)爱思唯尔科学公司，2001年。
We investigated whether creatine (CR) and beta -hydroxy-beta -methylbutyrate (HMB) act by similar or different mechanisms to increase lean body mass (LBM) and strength in humans undergoing progressive resistance-exercise training. in this double-blind, 3-wk study, subjects (n = 40) were randomized to placebo (PL, n = 10); CR (20.0 g of CR/d for 7 d followed by 10.0 g of CR/d for 14 d; n = 11),HMB (3.0 g of HMB/d; n = 9), or CR-and-HMB (CR/HMB; n = 10) treatment groups. Over 3 wk, all subjects gained LBM, which was assessed by bioelectrical impedance analysis. The CR, HMB and CR/HMB groups gained 0.92, 0.39, and 1.54 kg of LBM, respectively, over the placebo group, with a significant effect with CR supplementation (main effect P = 0.05) and a trend with HMB supplementation (main effect P = 0.08). These effects were additive because there was no interaction between CR and HMB (CR X HMB main effect,P = 0.73). Across all exercises, HMB, CR, and CR/HMB supplementation caused accumulative strength increases of 37.5, 39.1, and 51.9 kg, respectively, above the placebo group. The exercise-induced rise in serum creatine phosphokinase was markedly suppressed with HMB supplementation (main effect P = 0.01). However. CR supplementation antagonized the HMB effects on serum creatine phosphokinase (CR X HMB interactive effect P = 0.04). Urine urea nitrogen and plasma urea were not affected by CR supplementation, but both decreased with HMB supplementation (HMB effect P < 0.05), suggesting a nitrogen-sparing effect. In summary, CR and HMB can increase LBM and strength. and the effects are additive. Although not definitive, these results suggest thai CR and HMB act by different mechanisms. (C) Elsevier Science Inc. 2001.