Normal ocular development in young rhesus monkeys (Macaca mulatta)
Normal ocular development in young rhesus monkeys (Macaca mulatta)
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DOI：
10.1016/j.visres.2007.01.025
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发表时间：
2007-05-01
期刊：
影响因子：
1.8
通讯作者：
Smith, Earl L., III
中科院分区：
文献类型：
--
作者：
Qiao-Grider, Ying;Hung, Li-Fang;Smith, Earl L., III
目的：本研究的目的是表征幼猴的正常眼部发育，并建立人类和猴子屈光发育之间的定性和定量关系。方法：受试者为 214 只正常恒河猴。横断面数据是从 204 只大约 3 周龄的猴子中获得的，纵向数据是从 10 只代表性动物中获得的，从大约 3 周龄开始，持续长达 5 年。眼部发育通过屈光状态、角膜屈光度、晶状体参数和眼轴尺寸来表征，分别通过检影镜检查、角膜曲率测量、眼角膜测量和A扫描超声检查确定。结果：从出生到约5岁，屈光不正和大多数眼部成分（不包括晶状体厚度和等效晶状体指数）的增长曲线遵循指数轨迹，并且两只眼睛之间高度协调。然而，眼睛的整体生长并不是一个简单的按比例增加每个眼部成分规模的过程。相反，眼睛结构内部和之间的变化率和相对量有所不同。结论：婴儿和青少年猴子眼睛主要眼部成分的配置和贡献在质量和数量上与人眼非常相似，并且两个物种的发育过程相似。因此，在这两个物种中，青春期的眼睛不仅仅是婴儿眼睛的缩小版。 (C) 2007 Elsevier Ltd. 保留所有权利。
Purpose: The purpose of this study was to characterize normal ocular development in infant monkeys and to establish both qualitative and quantitative relationships between human and monkey refractive development.Methods: The subjects were 214 normal rhesus monkeys. Cross-sectional data were obtained from 204 monkeys at about 3 weeks of age and longitudinal data were obtained frorn 10 representative animals beginning at about 3 weeks of age for a period of up to 5 years. Ocular development was characterized via refractive status, corneal power, crystalline lens parameters, and the eye's axial dimensions, which were determined by retinoscopy, keratometry, phakometry and A-scan ultrasonography, respectively.Results: From birth to about 5 years of age, the growth curves for refractive error and most ocular components (excluding lens thickness and equivalent lens index) followed exponential trajectories and were highly coordinated between the two eyes. However, overall ocular growth was not a simple process of increasing the scale of each ocular component in a proportional manner. Instead the rates and relative amounts of change varied within and between ocular structures.Conclusion: The configuration and contribution of the major ocular components in infant and adolescent monkey eyes are qualitatively and quantitatively very comparable to those in human eyes and their development proceeds in a similar manner in both species. As a consequence, in both species the adolescent eye is not simply a scaled version of the infant eye. (C) 2007 Elsevier Ltd. All rights reserved.