Chemistry of sponges.: 19.: Novel bioactive metabolites from Hamigera tarangaensis
Chemistry of sponges.: 19.: Novel bioactive metabolites from Hamigera tarangaensis
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DOI：
10.1021/np9903494
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发表时间：
2000-01-01
影响因子：
5.1
通讯作者：
Bergquist, PR
中科院分区：
文献类型：
--
作者：
Wellington, KD;Cambie, RC;Bergquist, PR
从海绵Hamigera tarangasis中分离得到7个具有独特碳骨架的新化合物(1-6和10)，其中一个已报道的代谢物的结构由12修正为8。其结构经核磁共振确证。化合物3-6对P-388表现出中等的体外细胞毒性，而化合物3对疱疹病毒和脊髓灰质炎病毒都有100%的体外病毒抑制作用，只有轻微的细胞毒性。
Seven-new compounds (1-6 and 10) with a unique carbon skeleton have been isolated from the sponge Hamigera tarangaensis, and the structure of a previously reported metabolite has been revised from 12 to 8. The structures have been assigned from extensive NMR examination. Compounds 3-6 showed moderate in-vitro cytotoxicity against P-388, while 3 showed 100% in-vitro virus inhibition against both the Herpes and Polio viruses, with only slight cytotoxicity.