UK investments in global infectious disease research 1997-2010: a case study
UK investments in global infectious disease research 1997-2010: a case study
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DOI：
10.1016/s1473-3099(12)70261-x
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发表时间：
2013-01-01
影响因子：
56.3
通讯作者：
Atun, Rifat
中科院分区：
文献类型：
--
作者：
Head, Michael G.;Fitchett, Joseph R.;Atun, Rifat
传染病每年在全世界造成1500万人死亡，并且不成比例地影响年轻人、老年人和社会最贫困阶层。我们的目的是描述投资授予英国机构传染病research.Methods我们系统地搜索数据库和网站的信息，从资助机构的研究，并创建了一个全面的传染病研究项目的数据库期间1997-2010。我们按疾病、交叉主题以及描述科学类型的研发价值链对研究和资助进行了分类。回归分析报告与斯皮尔曼的秩相关系数，以建立研究投资，死亡率和疾病负担之间的关系，衡量残疾调整生命年（DALLS）。结果我们确定了6170资助的研究，与英国2.6英镑十亿英镑的总研究投资。与全球健康有关的研究占所有资金的35.6%（9.27亿英镑）。按疾病分列，艾滋病毒感染者获得4.61亿磅（17.7%），疟疾3.46亿英镑（13.3%），结核病1.49亿英镑（5.7%），流感80磅（3.1%），丙型肝炎60磅（2.3%）。我们将资金与疾病负担（死亡率和死亡率）进行了比较，结果显示，相对于胃肠道感染（2.54亿英镑，9.7%）、一些被忽视的热带疾病（1.84亿英镑，7.1%）和抗菌素耐药性（96亿英镑，3.7%）的负担，投资水平较低。病毒学是获得资助最多的类别（磅亿英镑，38.4%）。主要的资金来源是威康信托基金（6.88亿英镑，26.4%）和医学研究理事会（6.73亿英镑，25.8%）。资助机构和行业需要公开记录其研究投资，以纠正资源分配中的任何不公平现象。
Background Infectious diseases account for 15 million deaths per year worldwide, and disproportionately affect young people, elderly people, and the poorest sections of society. We aimed to describe the investments awarded to UK institutions for infectious disease research.Methods We systematically searched databases and websites for information on research studies from funding institutions and created a comprehensive database of infectious disease research projects for the period 1997-2010. We categorised studies and funding by disease, cross-cutting theme, and by a research and development value chain describing the type of science. Regression analyses were reported with Spearman's rank correlation coefficient to establish the relation between research investment, mortality, and disease burden as measured by disability-adjusted life years (DALYs).Findings We identified 6170 funded studies, with a total research investment of UK 2.6 pound billion. Studies with a dear global health component represented 35.6% of all funding (927 pound million). By disease, HIV received 461 pound million (17.7%), malaria 346 pound million (13.3%), tuberculosis 149 pound million (5.7%), influenza 80 pound minion (3.1%), and hepatitis C 60 pound million (2.3%). We compared funding with disease burden (DALYs and mortality) to show low levels of investment relative to burden for gastrointestinal infections (254 pound million, 9.7%), some neglected tropical diseases (184 pound million, 7.1%), and antimicrobial resistance (96 pound million, 3.7%). Virology was the highest funded category (1 pound billion, 38.4%). Leading funding sources were the Wellcome Trust (688 pound million, 26.4%) and the Medical Research Council (673 pound million, 25.8%).Interpretation Research funding has to be aligned with prevailing and projected global infectious disease burden. Funding agencies and industry need to openly document their research investments to redress any inequities in resource allocation.