Dermal Adipocytes: From Irrelevance to Metabolic Targets?
Dermal Adipocytes: From Irrelevance to Metabolic Targets?
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DOI：
10.1016/j.tem.2015.11.002
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Scherer PE
中科院分区：
文献类型：
--
作者：
Kruglikov IL;Scherer PE
真皮白色脂肪组织 (dWAT) 过去很少被认为是与更受认可的皮下白色脂肪组织 (sWAT) 不同的实体。然而，最近的研究表明 dWAT 对许多过程有重要贡献，包括免疫反应、伤口愈合和疤痕、毛囊生长和体温调节。独特的代谢贡献也归因于 dWAT，至少部分归因于隔热特性及其对寒冷暴露的反应。真皮脂肪细胞也可以经历脂肪细胞-肌成纤维细胞转变（AMT），这一过程被怀疑在皮肤内的许多病理生理过程中发挥重要作用。在这里，我们讨论有关 dWAT 生理学的新兴概念及其对各种细胞过程的重要性。
Dermal white adipose tissue (dWAT) has found little appreciation in the past as a distinct entity from the better recognized subcutaneous white adipose tissue (sWAT). However, recent work has established dWAT as an important contributor to a multitude of processes, including immune response, wound healing and scarring, hair follicle growth and thermoregulation. Unique metabolic contributions are attributed to dWAT as well, at least in part due to thermic insulation properties and its response to cold exposure. Dermal adipocytes can also undergo adipocyte-myofibroblast transition (AMT), a process that is suspected to play an important role in a number of pathophysiological processes within the skin. Here, we discuss emerging concepts regarding dWAT physiology and its significance to a variety of cellular processes.