MOSAIC ORGANIZATION OF DNA NUCLEOTIDES
MOSAIC ORGANIZATION OF DNA NUCLEOTIDES
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DOI：
10.1103/physreve.49.1685
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发表时间：
1994-02-01
影响因子：
2.4
通讯作者：
GOLDBERGER, AL
中科院分区：
文献类型：
--
作者：
PENG, CK;BULDYREV, SV;GOLDBERGER, AL
最近有报道称，含有非编码区的DNA序列具有长程幂律相关性。我们解决的问题，这种相关性是否可能是一个微不足道的后果，已知的镶嵌结构（“补丁”）的DNA。我们分析了两类控制组成的补丁核苷酸序列产生不同的算法，一个没有和一个具有长程幂律相关性。虽然这两种类型的序列是高度异质性的，它们是定量区分的替代波动分析方法，区分本地斑块从远程相关性。应用此分析选定的DNA序列表明，补丁是不足以占长程相关特性。
Long-range power-law correlations have been reported recently for DNA sequences containing noncoding regions. We address the question of whether such correlations may be a trivial consequence of the known mosaic structure (''patchiness'') of DNA. We analyze two classes of controls consisting of patchy nucleotide sequences generated by different algorithms-one without and one with long-range power-law correlations. Although both types of sequences are highly heterogeneous, they are quantitatively distinguishable by an alternative fluctuation analysis method that differentiates local patchiness from long-range correlations. Application of this analysis to selected DNA sequences demonstrates that patchiness is not sufficient to account for long-range correlation properties.