A noninvasive strategy for identifying and quantifying innocuous and nociceptive peripheral afferent activity evoked by nerve stimulation.
A noninvasive strategy for identifying and quantifying innocuous and nociceptive peripheral afferent activity evoked by nerve stimulation.
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一种无创策略，用于识别和量化由神经刺激引起的无害和伤害性外周传入活动。
DOI：
10.1016/0031-9384(93)90374-o
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发表时间：
1993
影响因子：
2.9
通讯作者：
Dowman,R
中科院分区：
文献类型：
--
作者：
Dowman,R
本研究评估了复合神经动作电位（CAP）和脊髓伤害性撤退（R3）反射在识别和量化人类腓肠神经刺激引起的外周传入活动中的效用。这项工作的结果表明，小于或等于引发最大 CAP 的电流可以被认为是完全无害的；提供进一步的证据证明 R3 是识别有害刺激水平的客观方法；并表明电流提供了整个无害和有害范围内传入活动的最佳无创定量估计。这项工作还表明，心理物理功能的一些个体差异可归因于影响到达神经的电流量的外围因素。因此，在研究电刺激产生的心理物理功能的个体差异时，考虑这些外围因素非常重要。
This study evaluated the utility of the compound nerve action potential (CAP) and spinal nociceptive withdrawal (R3) reflex in identifying and quantifying peripheral afferent activity evoked by sural nerve stimulation in humans. The results of this work demonstrate that currents less than or equal to that which elicits a just-maximal CAP can be considered purely innocuous; provide further evidence that the R3 is an objective means of identifying noxious stimulus levels; and suggest that current provides the best noninvasive quantitative estimate of afferent activity throughout the innocuous and noxious range. This work also demonstrates that some of the individual variability in the psychophysical function can be attributed to peripheral factors that affect the amount of current reaching the nerve. It is important, therefore, that these peripheral factors be considered when studying individual differences in the psychophysical function generated by electrical stimulation.