Intensity modulated proton therapy and its sensitivity to treatment uncertainties 1: the potential effects of calculational uncertainties
Intensity modulated proton therapy and its sensitivity to treatment uncertainties 1: the potential effects of calculational uncertainties
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DOI：
10.1088/0031-9155/53/4/014
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发表时间：
2008-02-21
影响因子：
3.5
通讯作者：
Lomax, A. J.
中科院分区：
文献类型：
--
作者：
Lomax, A. J.
研究了计算不确定性对三维和远端边缘跟踪（DET）调强质子治疗（IMPT）治疗计划的影响。通过比较分析和蒙特卡罗剂量计算评估了剂量计算的不确定性，并通过重新计算计划（所有CT值修改+/-3%）评估了潜在范围不确定性。两种计算方法之间PTV体积在+/- 3%范围内的分析表明，3D方法提供了显著改善的一致性（3D和DET方法分别为87.1%和80.3%）。对于DET方法，还发现CTV中的剂量由于CT值的3%变化而整体变化5%。当改变计划的场内梯度时，可以看到类似的趋势，但是也发现更复杂的计划对两种不确定性更敏感。总之，DET方法已被发现是相对敏感的计算误差在这里调查。相比之下，3D方法似乎相当稳健，除非存在强的内部梯度。然而，在评估所有形式的IMPT计划时，建议常规使用不确定性分析。
The effects of calculational uncertainties on 3D and distal edge tracking ( DET) intensity modulated proton therapy ( IMPT) treatment plans have been investigated. Dose calculation uncertainties have been assessed by comparing analytical and Monte Carlo dose calculations, and potential range uncertainties by recalculating plans with all CT values modified by +/- 3%. Analysis of the volume of PTV agreeing to within +/- 3% between the two calculations shows that the 3D approach provides significantly improved agreement ( 87.1 versus 80.3% of points for the 3D and DET approaches, respectively). For the DET approach, doses in the CTV have also been found to globally change by 5% as a result of 3% changes in CT value. When varying the intra- field gradients of the plans a similar trend is seen, but with the more complex plans also being found to be more sensitive to both uncertainties. In conclusion, the DET approach has been found to be relatively sensitive to the calculational errors investigated here. In contrast, the 3D approach appears to be quite robust, unless strong internal gradients are present. Nevertheless, the routine use of uncertainty analysis is advised when assessing all forms of IMPT plans.