The Frequency of Type 2 CD8+ T Cells Is Increased in Peripheral Blood from Patients with Psoriasis Vulgaris
The Frequency of Type 2 CD8+ T Cells Is Increased in Peripheral Blood from Patients with Psoriasis Vulgaris
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寻常型银屑病患者外周血中 2 型 CD8 T 细胞的频率增加
DOI：
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发表时间：
2003
影响因子：
9.1
通讯作者：
K. Takehara
中科院分区：
文献类型：
--
作者：
M. Inaoki;S. Sato;F. Shirasaki;N. Mukaida;K. Takehara
研究表明，寻常型银屑病是由1型T细胞介导的。在这项研究中，我们研究了趋化因子受体的表达和细胞内细胞因子的生产循环T细胞检查1型/2型银屑病的平衡。CCR 4+和CXCR 3 + T细胞分别主要产生白细胞介素-4和干扰素-γ。银屑病患者和健康对照组外周血CD 4 + T细胞中产生干扰素-γ的细胞和CXCR 3+细胞的频率相似。相比之下，银屑病患者中CCR 4 + CD 8 + T细胞的频率和循环CD 8 + T细胞中CCR 4/CXCR 3的比率显著高于健康对照组。细胞内细胞因子产生的分析也表明银屑病患者外周血中2型CD 8 + T（Tc 2）细胞的相对增加。循环中Tc 2细胞的频率与银屑病面积和严重程度指数直接相关。免疫组化结果显示，银屑病患者表皮和真皮中不仅有CXCR 3 + CD 8 + T细胞浸润，而且有数量相近的CCR 4 + CD 8 + T细胞浸润。我们的研究结果表明银屑病患者血液中Tc 2细胞数量增加，以及Tc 2细胞与银屑病炎症的相关性。
Studies have suggested that psoriasis vulgaris is mediated by type 1 T cells. In this study, we examined both chemokine receptor expression and intracellular cytokine production by circulating T cells to check the type 1/type 2 balance in psoriasis. CCR4+ and CXCR3+ T cells predominantly produced interleukin-4 and interferon-γ, respectively. The frequency of interferon-γ-producing cells and that of CXCR3+ cells in circulating CD4+ T cells were similar for psoriatic patients and healthy control subjects. By contrast, the frequency of CCR4+CD8+ T cells and CCR4/CXCR3 ratio in circulating CD8+ T cells were significantly higher in psoriatic patients than in healthy control subjects. Analysis of intracellular cytokine production also indicated relative increase of type 2 CD8+ T (Tc2) cells in peripheral blood from psoriatic patients. The frequency of circulating Tc2 cells directly correlated with Psoriasis Area and Severity Index. Immunohistochemical analysis showed that not only CXCR3+CD8+ T cells but also a similar number of CCR4+CD8+ T cells infiltrated the psoriatic epidermis and dermis. Our findings suggest an increase in Tc2 cell number in blood from psoriatic patients, and the association of Tc2 cells with inflammation in psoriasis.
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影响因子：
56.9
作者：
SALGAME, P;ABRAMS, JS;BLOOM, BR
通讯作者：
BLOOM, BR
影响因子：
32.4
作者：
Sato, S;Miller, AS;Tedder, TF
通讯作者：
Tedder, TF
影响因子：
6.5
作者：
UYEMURA, K;YAMAMURA, M;NICKOLOFF, BJ
通讯作者：
NICKOLOFF, BJ
影响因子：
6.5
作者：
Szabo, SK;Hammerberg, C;Cooper, KD
通讯作者：
Cooper, KD
角质形成细胞 CDw60 表达受 Th-1 型细胞因子 IFN-γ 和 Th-2 细胞因子 IL-4 和 IL-13 调节：与银屑病相关。
DOI：
10.1046/j.1523-1747.2001.01242.x
发表时间：
2001
期刊：
The Journal of investigative dermatology.
影响因子：
--
作者：
Huang,BB;Bonish,BK;Chaturvedi,V;Qin,JZ;Nickoloff,BJ
通讯作者：
Nickoloff,BJ