Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells.
Direct activation of CD8+ cytotoxic T lymphocytes by dendritic cells.
复制标题
树突状细胞直接激活CD8+细胞毒性T淋巴细胞。
DOI：
10.1084/jem.166.1.182
复制
发表时间：
1987-07-01
影响因子：
15.3
通讯作者：
STEINMAN, RM
中科院分区：
文献类型：
--
作者：
INABA, K;YOUNG, JW;STEINMAN, RM
Recent experiments (11-13) have shown that antigen-specific, CD8+, CD4- T lymphocytes can be induced to proliferate and become killer cells in the absence of a second population of "helper" CD8-, CD4+ cells. We have studied early events in the activation of CD4+ and CD8+ T cell subsets in the primary mixed leukocyte reaction. Dendritic cells are a major if not essential accessory cell for the activation of both subpopulations. Antigen-bearing macrophages fail to stimulate unprimed CD8+ cells, but act as targets for the sensitized cytolytic lymphocytes that are induced by dendritic cells. The initial proliferative response is comparable for CD4+ and CD8+ lymphocyte subsets. For both subpopulations, dendritic cells efficiently cluster the responding lymphocytes on the first day and induce the release of IL-2. The data indicate that CD4+ and CD8+ lymphocytes can be activated by a similar mechanism, and illustrate the special role of dendritic cells in the sensitization stage of cell-mediated immunity.
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DOI：
10.1084/jem.157.4.1101
发表时间：
1983-04-01
期刊：
The Journal of experimental medicine
影响因子：
--
作者：
Austyn JM;Steinman RM;Weinstein DE;Granelli-Piperno A;Palladino MA
通讯作者：
Palladino MA
影响因子：
15.3
作者：
MIZUOCHI, T;ONO, S;SINGER, A
通讯作者：
SINGER, A
影响因子：
15.3
作者：
Inaba, K;Steinman, R M
通讯作者：
Steinman, R M
影响因子：
8.7
作者：
BACH, FH;GRILLOTCOURVALIN, C;BACH, ML
通讯作者：
BACH, ML
影响因子：
15.3
作者：
INABA, K;STEINMAN, RM
通讯作者：
STEINMAN, RM