NF-κB is activated and promotes cell death in focal cerebral ischemia
NF-κB is activated and promotes cell death in focal cerebral ischemia
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DOI：
10.1038/8432
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发表时间：
1999-05-01
期刊：
影响因子：
82.9
通讯作者：
Schwaninger, M
中科院分区：
文献类型：
--
作者：
Schneider, A;Martin-Villalba, A;Schwaninger, M
转录因子nf - κ B是细胞死亡或存活的调节因子。为了探讨nf - κ B在脑卒中鼠模型中神经元细胞死亡中的作用，我们研究了nf - κ B在脑卒中鼠模型中的活化。在缺血半球，NF-kappa B被激活，这可以通过NF-kappa B驱动的报告基因表达增加、NF-kappa B在神经元中的核易位以及NF-kappa B亚基RelA和p50的DNA结合增强来确定。在p50基因敲除小鼠中，缺血性损伤明显减轻。这表明nf - κ B在局灶性缺血中具有促进细胞死亡的作用。NF-kappa B可能为神经系统疾病提供新的药理靶点。
The transcription factor NF-kappa B is a regulator of cell death or survival. To investigate the role of NF-kappa B in neuronal cell death, we studied its activation in a rodent model of stroke. In the ischemic hemisphere, NF-kappa B was activated, as determined by increased expression of an NF-kappa B-driven reporter transgene, nuclear translocation of NF-kappa B in neurons and enhanced DNA binding of NF-kappa B subunits RelA and p50. In p50 knockout mice, ischemic damage was significantly reduced. This indicates a cell death-promoting role of NF-kappa B in focal ischemia. NF-kappa B may provide a new pharmacological target in neurologic disease.