Mn2+-doped NaYF4:Yb/Er upconversion nanoparticle-based electrochemiluminescent aptasensor for bisphenol A
Mn2+-doped NaYF4:Yb/Er upconversion nanoparticle-based electrochemiluminescent aptasensor for bisphenol A
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DOI：
10.1007/s00216-016-9470-7
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发表时间：
2016-05-01
影响因子：
4.3
通讯作者：
Wang, Zhouping
中科院分区：
文献类型：
--
作者：
Guo, Xiaofei;Wu, Shijia;Wang, Zhouping
采用Mn2+掺杂的NaYF4:Yb/Er上转换纳米粒子（NaYF4:Yb,Er/Mn UCNPs）标记了一种新型适配体传感器，用于电致化学发光（ECL）对双酚A （BPA）的灵敏检测。将巯基化的BPA适体共价固定在金纳米粒子修饰的电极上，并与以NaYF4:Yb，Er/Mn UCNPs标记的互补DNA配对，组装ECL适体传感器。ECL感应传感器不仅能够快速准确地检测0.05 ~ 100 ng/mL的BPA浓度，检出限为0.037 ng/mL，而且基于上转换纳米颗粒作为一种有前景的替代材料，为ECL应用提供了新的平台。
A novel aptasensor labeled with Mn2+-doped NaYF4:Yb/Er upconversion nanoparticles (NaYF4:Yb,Er/Mn UCNPs) was employed in electrogenerated chemiluminescence (ECL) for the sensitive detection of bisphenol A (BPA). The ECL aptasensor was assembled by immobilizing the thiolated aptamers of BPA covalently on a gold nanoparticle (AuNPs)-modified electrode and pairing with complementary DNA labeled with NaYF4:Yb,Er/Mn UCNPs. The ECL aptasensor can not only rapidly and accurately detect BPA concentrations from 0.05 to 100 ng/mL with a detection limit of 0.037 ng/mL but also provides a new platform for ECL applications based on the use of upconversion nanoparticles as a promising alternative material.