5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: evidence from the English and Romanian Adoptee (ERA) study
5HTT genotype moderates the influence of early institutional deprivation on emotional problems in adolescence: evidence from the English and Romanian Adoptee (ERA) study
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DOI：
10.1111/j.1469-7610.2010.02249.x
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发表时间：
2010-07-01
影响因子：
7.6
通讯作者：
Sonuga-Barke, Edmund J. S.
中科院分区：
文献类型：
--
作者：
Kumsta, Robert;Stevens, Suzanne;Sonuga-Barke, Edmund J. S.
背景：5-羟色胺转运体基因(SLC6A4，5HTT)是一种常见的多态基因，其在儿童时期的逆境和应激性生活事件对精神病理学发展的影响中起到调节作用。利用英国和罗马尼亚被领养者研究的数据，对125名暴露于严重早期制度剥夺(ID)的个人(n=125)进行前瞻性纵向研究，检验ID对青少年情绪问题的影响是否受5HTT基因和青春期应激生活事件的调节。方法：使用问卷数据(11岁)和CAPA诊断性访谈(15岁)评估情绪问题。结果：在测试时，与年龄无关的基因x环境交互作用(p=0.008)和基因x环境交互作用(p=0.003)有显著影响。重度ID组中S/L、S/S等位基因携带者的情绪问题得分最高，而L/L纯合子总体水平最低。重度ID组S/S携带者在11~15岁期间经历大量应激性生活事件的情绪问题得分增幅最大，而紧张性生活事件数目少的携带者情感问题得分下降幅度最大(4向交互作用：P=0.05)。结论：早期重度ID对青春期情绪问题的影响受5HTT基因的调节，并受青春期应激性生活事件的影响。
Background:A common polymorphism in the serotonin transporter gene (SLC6A4, 5HTT) has been repeatedly shown to moderate the influence of childhood adversity and stressful life events on the development of psychopathology. Using data from the English and Romanian Adoptee Study, a prospective-longitudinal study of individuals (n = 125) exposed to severe early institutional deprivation (ID), we tested whether the effect of ID on adolescent emotional problems is moderated by 5HTT genotype and stressful life events in adolescence.Methods:Emotional problems were assessed using questionnaire data (age 11), and on the basis of the CAPA diagnostic interview (age 15). Additionally, the number of stressful life events was measured.Results:There was a significant effect for genotype (p = .003) and a gene x environment interaction (p = .008) that was independent of age at testing. Carriers of the s/l and s/s genotype who experienced severe ID showed the highest emotional problem scores, while l/l homozygotes in the severe ID group showed the lowest overall levels. Furthermore, s/s carriers in the severe ID group who experienced a high number of stressful life events between 11 and 15 years had the largest increases in emotional problem scores, while a low number of stressful life events was associated with the largest decrease (4-way interaction: p = .05).Conclusions:The effects of severe early ID on emotional problems in adolescence are moderated by 5HTT genotype, and influenced by stressful life events in adolescence.