Activation of the hypothalamus characterizes the acupuncture stimulation at the analgesic point in human: a positron emission tomography study
Activation of the hypothalamus characterizes the acupuncture stimulation at the analgesic point in human: a positron emission tomography study
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DOI：
10.1016/s0304-3940(01)01952-8
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发表时间：
2001-07-13
影响因子：
2.5
通讯作者：
Ho, LT
中科院分区：
文献类型：
--
作者：
Hsieh, JC;Tu, CH;Ho, LT
我们进行了正电子发射断层扫描研究，使用局部脑血流量作为大脑活动的指标，通过在经典镇痛点进行短时间针刺刺激来解决大脑激活模式的特异性。在正常人中，分别在镇痛效果显著的经典点（李4，合谷）和附近的非经典/非镇痛点进行2 Hz的针刺手法。针刺刺激激活的区域包括下丘脑，延伸到中脑，小脑，前扣带皮层和小脑。值得注意的是，只有在F14处的刺激在与分别由两个点处的刺激引起的针灸感觉（得气）的类似心理物理评级下激活下丘脑。这些结果提示，下丘脑可能是经典痛点针刺效应的中枢表达，是介导针刺镇痛效应的关键因素之一。(C)2001爱思唯尔科学爱尔兰有限公司保留所有权利。
We performed a positron emission tomography study, using regional cerebral blood flow as the index of brain activity, to address the specificity of brain activation pattern by acupuncture stimulation of short duration at the classical analgesic point. Needling manipulation at 2 Hz was performed at a classical point of prominent analgesic efficacy (Li 4, Heku) and a near-by non-classical/non-analgesic point, respectively, in normal subjects. Regions activated by acupuncture stimulation at Li 4 included the hypothalamus with an extension to midbrain, the insula, the anterior cingulate cortex, and the cerebellum. Of note, it was only the stimulation at Fi 4 that activated the hypothalamus under the similar psychophysical ratings of acupuncture sensation (deqi) as elicited by the stimulation at the two points, respectively. The data suggested that the hypothalamus might characterize the central expression of acupuncture stimulation at the classical analgesic point and serve as one key element in mediating analgesic efficacy of acupuncture stimulation. (C) 2001 Elsevier Science Ireland Ltd. All rights reserved.