Macronutrient composition influence on breast cancer risk in Hispanic and non-Hispanic white women: the 4-Corners Breast Cancer Study.
Macronutrient composition influence on breast cancer risk in Hispanic and non-Hispanic white women: the 4-Corners Breast Cancer Study.
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DOI：
10.1080/01635581.2011.523499
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发表时间：
2011
期刊：
影响因子：
--
通讯作者：
Slattery M
中科院分区：
文献类型：
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作者：
Murtaugh MA;Herrick J;Sweeney C;Guiliano A;Baumgartner K;Byers T;Slattery M
膳食常量营养素组成与乳腺癌风险之间的关系尚未得到很好的理解。我们在四角乳腺癌研究中调查了饮食的常量营养素组成。Logistic回归模型用于病例对照比较，调整了年龄、中心、教育、吸烟、总活动、热量、膳食纤维、膳食钙、身高、产次、近期激素暴露、参考年体重指数（BMI）以及BMI与近期激素暴露的相互作用。乳腺癌风险随着饮食脂肪的增加而下降，随着碳水化合物的增加而增加，在种族和绝经状态中相似。碳水化合物（直接）和脂肪（反向），特别是饱和脂肪和单不饱和脂肪，与乳腺癌的关联存在于正常和超重的绝经后妇女中，而肥胖的绝经后妇女中不存在。在非西班牙裔白色和西班牙裔女性之间，大量营养素与乳腺癌风险的相关性没有实质性差异。在绝经后肥胖妇女中，大量营养素、碳水化合物和脂肪与乳腺癌风险之间的关系减弱。
The association of dietary macronutrient composition with risk of breast cancer is not well understood. We investigated the macronutrient composition of diet in the 4-Corners Breast Cancer Study. Logistic regression models were used for case-control comparisons adjusted for age, center, education, smoking, total activity, calories, dietary fiber, dietary calcium, height, parity, recent hormone exposure, reference year body mass index (BMI), and the interaction of BMI and recent hormone exposure. Breast cancer risk declined with increasing dietary fat and increased with carbohydrates similarly across ethnicity and menopausal status. Associations of carbohydrate (direct) and fat (inverse), particularly saturated and monounsaturated fat, with breast cancer were present among normal and overweight postmenopausal women and absent among obese postmenopausal women. No substantive differences were noted in the association of macronutrients with risk of breast cancer between non-Hispanic white and Hispanic women. Associations of the macronutrients carbohydrate and fat with breast cancer risk were attenuated among postmenopausal obese women.