Nitric oxide:: A useful gas in the detection of lower urinary tract inflammation
Nitric oxide:: A useful gas in the detection of lower urinary tract inflammation
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DOI：
10.1016/s0022-5347(05)68551-5
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发表时间：
1999-08-01
影响因子：
6.6
通讯作者：
Wiklund, NP
中科院分区：
文献类型：
--
作者：
Ehrén, I;Hosseini, A;Wiklund, NP
目的：各种病因的膀胱炎患者膀胱腔内一氧化氮水平升高。我们确定管腔一氧化氮是否可以用作区分炎症（即间质性膀胱炎）与非炎症性疾病（例如流出道梗阻和神经源性功能障碍）引起的尿急、尿频、尿急和疼痛的标记物。材料和方法：我们测量了逼尿肌不稳定（6例），流出道梗阻（7例），感觉冲动（19）和间质性膀胱炎（8），以及无尿急症状的对照组（11）。将无一氧化氮的空气在膀胱中孵育5分钟，并在化学发光一氧化氮分析仪中进行分析。间质性膀胱炎患者平均膀胱一氧化氮浓度增加近20倍（234 +/-67ppb）与逼尿肌不稳定患者相比（11 +/-1）、流出道阻塞（9 +/-1）和感觉紧迫（10 +/-1）和对照组（13 +/-2）.结论：测量膀胱空气中的一氧化氮是一种简单，一种安全、快速的方法来区分炎症引起的尿急与神经源性疾病或流出道阻塞。这种方法的简单性使其成为办公室使用的潜在有用的筛选方法。
Purpose: Luminal nitric oxide has been shown to be elevated in the bladder of patients with cystitis of various etiologies. We determine whether luminal nitric oxide can be used as a marker to differentiate inflammation, that is interstitial cystitis, from urgency, frequency, nocturia and pain due to noninflammatory disorders, such as outflow obstruction and neurogenic dysfunction.Materials and Methods: We measured luminal nitric oxide in the bladder of patients with urgency due to detrusor instability (6), outflow obstruction (7), sensory urge (19) and interstitial cystitis (8), and controls without urgency symptoms (11). Nitric oxide-free air was incubated in the bladder for 5 minutes and analyzed in a chemiluminescence nitric oxide analyzer.Results: There was a nearly 20-fold increase in mean bladder nitric oxide concentration in patients with interstitial cystitis (234 +/- 67 parts per billion) compared to those with detrusor instability (11 +/- 1), outflow obstruction (9 +/- 1) and sensory urgency (10 +/- 1), and controls (13 +/- 2).Conclusions: Measurement of nitric oxide in air from the bladder is a simple, safe and fast method to differentiate urgency due to inflammation from neurogenic disorders or outflow obstruction. The simplicity of this method makes it potentially useful as a screening method for office use.