Role of GABAB receptors in the control of hypoglossal motoneurons in vivo.
Role of GABAB receptors in the control of hypoglossal motoneurons in vivo.
复制标题
GABAB 受体在体内舌下运动神经元控制中的作用。
DOI：
10.1097/00001756-199412000-00042
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发表时间：
1994
期刊：
影响因子：
1.7
通讯作者：
Kubin,L
中科院分区：
文献类型：
--
作者：
Okabe,S;Woch,G;Kubin,L
关于GABA - B受体介导的口面部运动神经元作用的研究很少。我们记录了聚氨酯麻醉、麻痹、迷走神经切断和人工通气大鼠舌下（XII）神经的吸气活动。将GABA B受体激动剂巴氯芬或拮抗剂CGP-35348微注射到一个XII核中。巴氯芬以剂量依赖性的方式迅速降低XII神经活动50%以上。拮抗剂可延迟抑制40%的活性。结果表明：(1)在本实验条件下，十二核内的GABA B受体可能抑制吸气十二运动神经元的活性，但不具有强直活性；(2)在XII运动神经元中存在一种净内源性兴奋作用，这种兴奋作用是由位于XII核周围网状结构中的GABA B受体介导的。
THERE is little information on GABA B receptor-mediated effects on orofacial motoneurons. We recorded the inspiratory activity from both hypoglossal (XII) nerves in urethane-anesthetized, paralyzed, vagotomized and artificially ventilated rats. A GABA B receptor agonist, baclofen, or antagonist, CGP-35348, was microinjected into one XII nucleus. Baclofen rapidly reduced the XII nerve activity in a dose-dependent manner by over 50%. The antagonist caused a delayed suppression of activity by 40%. We conclude that:(1) GABA B receptors within the XII nucleus may suppress the activity of inspiratory XII motoneurons, but they are not tonically active under the conditions of our experiment;(2) there is a net endogenous excitatory effect in XII motoneurons that is mediated by GABA B receptors located in the reticular formation surrounding the XII nucleus.