Association Between Attention-Deficit/Hyperactivity Disorder in Adolescence and Substance Use Disorders in Adulthood
Association Between Attention-Deficit/Hyperactivity Disorder in Adolescence and Substance Use Disorders in Adulthood
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DOI：
10.1001/archpediatrics.2010.180
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发表时间：
2010-10-01
影响因子：
--
通讯作者：
Koppel, Jonathan
中科院分区：
文献类型：
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作者：
Brook, David W.;Brook, Judith S.;Koppel, Jonathan
目的：为了确定是否注意力缺陷/多动障碍（ADHD）在青春期与物质使用障碍（SUDs）在成年期，是否进行障碍（CD）介导这种关系。设计：一个前瞻性设计纳入5个评估的参与者跨越平均年龄14至37岁。在14岁和16岁时进行了两次基线评估，在27岁和37岁之间进行了3次结果评估。设置：美国。参与者：1975年从纽约北部抽取的个人社区样本，观察到平均年龄为37岁。干预措施：诊断面试时间表的儿童被用来评估ADHD和CD和密歇根大学的复合国际诊断面试被用来评估SUDs.Main Outcome Measure：A diagnosis of SUDs given to participants in adulthood.Results：The odds ratio for ADHD and CD in adolescent as related to SUDs in adulthood. The odds ratio for ADHD and CD in adolescent分别为1.9和3.5。ADHD和SUDs之间的关联，但是，是间接的，因为CD作为ADHD和SUDs之间的调解人。结论：儿科医生应该把重点放在青少年ADHD时，它进展到CD，因为CD是一个主要的预测SUDs在成年期。
Objectives: To determine whether attention-deficit/hyperactivity disorder (ADHD) in adolescence is related to substance use disorders (SUDs) in adulthood and whether conduct disorder (CD) mediates this relationship.Design: A prospective design incorporating 5 assessments in participants spanning the mean ages of 14 to 37 years. Two baseline assessments were taken at ages 14 and 16 years, and 3 outcome assessments were taken between ages 27 and 37 years.Setting: United States.Participants: A community sample of individuals initially drawn from upstate New York in 1975 and observed to a mean age of 37 years. Interventions: The Diagnostic Interview Schedule for Children was used to assess ADHD and CD and the University of Michigan Composite International Diagnostic Interview was used to assess SUDs.Main Outcome Measure: A diagnosis of SUDs given to participants in adulthood.Results: The odds ratios for ADHD and CD in adolescence as related to SUDs in adulthood were 1.9 and 3.5, respectively. The association between ADHD and SUDs, however, was indirect because CD served as a mediator between ADHD and SUDs.Conclusions: Pediatricians should focus on adolescent ADHD when it progresses to CD because CD is a major predictor of SUDs in adulthood.