H3K9me3-Dependent Heterochromatin: Barrier to Cell Fate Changes.
H3K9me3-Dependent Heterochromatin: Barrier to Cell Fate Changes.
复制标题
H3K9ME3依赖性异染色质：细胞命运变化的屏障。
DOI：
10.1016/j.tig.2015.11.001
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发表时间：
2016-01
期刊：
影响因子：
--
通讯作者：
Zaret KS
中科院分区：
文献类型：
--
作者：
Becker JS;Nicetto D;Zaret KS
建立和维持细胞身份依赖于基因表达的适当调节，如转录因子所指定的和表观遗传机制所加强的。在表观遗传机制中，异染色质的形成对于保持基因组稳定性和细胞类型特异性基因沉默至关重要。异染色质相关的组蛋白标记H3K9me3，虽然传统上与基因组的非编码部分相关，但已成为抑制谱系不适当基因并使其免受转录因子激活的关键参与者。在这里，我们描述了H3K9me3异染色质在阻碍细胞身份重编程中的作用，以及H3K9me3在发育和细胞命运决定过程中重组的机制。
Establishing and maintaining cell identity depends upon the proper regulation of gene expression, as specified by transcription factors and reinforced by epigenetic mechanisms. Among the epigenetic mechanisms, heterochromatin formation is critical for the preservation of genome stability and the cell type-specific silencing of genes. The heterochromatin-associated histone mark H3K9me3, although traditionally associated with the noncoding portions of the genome, has emerged as a key player in repressing lineage-inappropriate genes and shielding them from activation by transcription factors. Here we describe the role of H3K9me3 heterochromatin in impeding the reprogramming of cell identity and the mechanisms by which H3K9me3 is reorganized during development and cell fate determination.