Change-Driven M100 Component in the Bilateral Secondary Somatosensory Cortex: A Magnetoencephalographic Study
Change-Driven M100 Component in the Bilateral Secondary Somatosensory Cortex: A Magnetoencephalographic Study
复制标题
双侧次级体感皮层中变化驱动的 M100 成分：脑磁图研究
DOI：
10.1007/s10548-018-0687-y
复制
发表时间：
2018
期刊：
影响因子：
2.7
通讯作者：
Maruyama Atsuo
中科院分区：
文献类型：
--
作者：
Yamashiro Koya;Sato Daisuke;Onishi Hideaki;Sugawara Kazuhiro;Otsuru Naofumi;Kirimoto Hikari;Nakazawa Sho;Yamazaki Yudai;Shirozu Hiroshi;Maruyama Atsuo
我们以前的演示，M100体感诱发磁场（SEF）有一个类似的时间剖面，偶极子方向和源位置是否引起激活（ON-M100）或失活（OFF-M100）的电刺激表明一个共同的皮层系统来检测感觉变化。虽然我们没有使用电刺激记录比M100更早的这种变化驱动的分量，但是使用ON和OFF机械刺激都报告了清楚的M50响应（Onishi等人，Clin Neurophysiol 121：588-593，2010）。为了研究M50和M100在反映体感变化检测中的意义，我们记录了这些波形在12名健康受试者（9男3女）脑磁图响应于压电致动器的机械刺激。发作和偏移（ON和OFF）刺激随机呈现三个先前的稳态（PSS）持续时间（0.5，1.5和3秒）在一个连续的会话。结果表明：（i）起始和终止体感事件引出了清晰的M50和M100成分;（ii）M50和M100成分有不同的起源，M50位于对侧初级体感皮层（cS 1），M100位于双侧次级体感皮层（iii）CS 1中M50的振幅与PSS持续时间无关，而CS 2中M100的振幅则依赖于ON和OFF事件的PSS持续时间。这些研究结果表明，在cS 1的M50振幅反映了在发病和偏移过程中激活的机械感受器的数量，而在S2的M100振幅反映了变化检测的基础上的感觉记忆的发病和偏移刺激至少部分。我们证明了在体感通道中，cS 1的M50和S2的M100在变化检测系统中起着不同的作用。
Our previous demonstration that the M100 somatosensory evoked magnetic field (SEF) has a similar temporal profile, dipole orientation and source location whether induced by activation (ON-M100) or deactivation (OFF-M100) of electrical stimulation suggests a common cortical system to detect sensory change. While we have not recorded such change-driven components earlier than M100 using electrical stimulation, clear M50 responses were reported using both ON and OFF mechanical stimulation (Onishi et al. in Clin Neurophysiol 121:588–593, 2010). To examine the significance of M50 and M100 in reflecting the detection of somatosensory changes, we recorded these waveforms in 12 healthy subjects (9 males and 3 females) by magnetoencephalography in response to mechanical stimulation from a piezoelectric actuator. Onset and offset (ON and OFF) stimuli were randomly presented with three preceding steady state (PSS) durations (0.5, 1.5 and 3 s) in one consecutive session. Results revealed that (i) onset and offset somatosensory events elicited clear M50 and M100 components; (ii) M50 and M100 components had distinct origins, with M50 localised to the contralateral primary somatosensory cortex (cS1) and M100 to the bilateral secondary somatosensory cortex (iS2, cS2); and (iii) the amplitude of M50 in cS1 was independent of the PSS durations, whereas that of M100 in S2 was dependent on the PSS durations for both ON and OFF events. These findings suggest that the M50 amplitude in cS1 reflects the number of activated mechanoreceptors during Onset and Offset, whereas the M100 amplitude in S2 reflects change detection based on sensory memory for Onset and Offset stimuli at least in part. We demonstrated that the M50 in cS1 and M100 in S2 plays different roles in the change detection system in somatosensory modality.