TRIALS OF INFLUENZA A-NEW-JERSEY-76 VIRUS-VACCINE IN NORMAL CHILDREN - OVERVIEW OF AGE-RELATED ANTIGENICITY AND REACTOGENICITY
TRIALS OF INFLUENZA A-NEW-JERSEY-76 VIRUS-VACCINE IN NORMAL CHILDREN - OVERVIEW OF AGE-RELATED ANTIGENICITY AND REACTOGENICITY
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DOI：
10.1093/infdis/136.supplement_3.s731
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发表时间：
1977-01-01
影响因子：
6.4
通讯作者：
KARZON, DT
中科院分区：
文献类型：
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作者：
WRIGHT, PF;THOMPSON, J;KARZON, DT
范德比尔特大学（纳什维尔，田纳西州）收集并总结了在2,326名正常儿童中进行的灭活单价A/新泽西/76流感病毒疫苗试验的全部多中心数据。这些组合数据提供了每个生产商疫苗的相对抗原性和反应原性的最佳测量。10岁以下的儿童被证明对含有50个鸡细胞凝集单位的全病毒疫苗剂量有疫苗相关反应。裂解病毒疫苗在8倍的剂量下耐受性良好。没有一种疫苗在单剂量下具有令人满意的抗原性。裂解病毒疫苗的两剂方案具有抗原性，并且该方案与急性反应无关。
The total multicenter data from trials with inactivated monovalent influenza A/New Jersey/76 virus vaccine in 2,326 normal children were collected and summarized at Vanderbilt University (Nashville, Tenn.). These combined data provided the best measure of the relative antigenicity and reactogenicity of each manufacturer's vaccine. Children younger than 10 years of age were shown to have vaccine-associated reactions to doses of whole-virus vaccine containing as little as 50 chick cell-agglutinating units. Split-virus vaccines were well tolerated in doses eight times as high. No vaccine was satisfactorily antigenic in a single dose. A two-dose regimen of splitvirus vaccine was antigenic, and this regimen was not associated with acute reactions.