Transdermal Composite Microneedle Composed of Mesoporous Iron Oxide Nanoraspberry and PVA for Androgenetic Alopecia Treatment
Transdermal Composite Microneedle Composed of Mesoporous Iron Oxide Nanoraspberry and PVA for Androgenetic Alopecia Treatment
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DOI：
10.3390/polym12061392
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发表时间：
2020-06-01
期刊：
影响因子：
5
通讯作者：
Hu, Shang-Hsiu
中科院分区：
文献类型：
--
作者：
Fang, Jen-Hung;Liu, Che-Hau;Hu, Shang-Hsiu
放大活性分子的局部浓度的治疗剂的经皮递送在广泛的生物医学应用中，特别是在疫苗开发和医疗美容中受到相当大的关注。与口服或皮下注射不同，这种方法不仅可以避免口服药物由于肝脏的首过效应而失去疗效，还可以降低皮下注射感染的风险。在这项研究中，磁响应透皮复合微针（MN）与介孔氧化铁纳米aspberry（MIO），可以提高药物输送效率，通过使用3D打印成型方法。通过负载米诺地尔（Mx，一种通常用于减缓脱发进展和加速毛发再生过程的药物），MN可以通过穿刺能力打破角质层屏障，并控制用于治疗雄激素性脱发（阿加）的递送剂量。通过3D打印过程，MN的尺寸和形态能够被容易地构造。将米奥斯嵌入MN的尖端，MN可以递送Mx并产生用于毛发生长的温和加热，这可能归因于毛囊的扩张和药物渗透。与未进行任何处理的小鼠相比，在处理后10天，用MF处理MN后，小鼠的毛发密度显示出800%的改善。
The transdermal delivery of therapeutic agents amplifying a local concentration of active molecules have received considerable attention in wide biomedical applications, especially in vaccine development and medical beauty. Unlike oral or subcutaneous injections, this approach can not only avoid the loss of efficacy of oral drugs due to the liver's first-pass effect but also reduce the risk of infection by subcutaneous injection. In this study, a magneto-responsive transdermal composite microneedle (MNs) with a mesoporous iron oxide nanoraspberry (MIO), that can improve the drug delivery efficiency, was fabricated by using a 3D printing-molding method. With loading of Minoxidil (Mx, a medication commonly used to slow the progression of hair loss and speed the process of hair regrowth), MNs can break the barrier of the stratum corneum through the puncture ability, and control the delivery dose for treating androgenetic alopecia (AGA). By 3D printing process, the sizes and morphologies of MNs is able to be, easily, architected. The MIOs were embedded into the tip of MNs which can deliver Mx as well as generate mild heating for hair growth, which is potentially attributed by the expansion of hair follicle and drug penetration. Compared to the mice without any treatments, the hair density of mice exhibited an 800% improvement after being treated by MNs with MF at 10-days post-treatment.