Tungsten disulfide-based nanocomposites for photothermal therapy
Tungsten disulfide-based nanocomposites for photothermal therapy
复制标题
DOI：
10.3762/bjnano.10.81
复制
发表时间：
2019-04-02
影响因子：
3.1
通讯作者：
Lellouche, Jean-Paul
中科院分区：
文献类型：
--
作者：
Levin, Tzuriel;Sade, Hagit;Lellouche, Jean-Paul
过渡金属二硫属化物（TMDC）的纳米结构在过去几十年引起了科学界的兴趣。二硫化钨 (WS2) 纳米管和纳米颗粒是该组中研究最广泛的成员之一，用于聚合物增强、润滑和电子设备等。它们的生物相容性和低毒性使其适合医学和生物应用。一个潜在的应用是光热疗法（PTT），这是一种癌症靶向治疗方法，其中用近红外范围的激光照射光响应材料。在本文中，我们介绍了用先前报道的硝酸高铈铵磁赤铁矿 (CAN-mag) 纳米粒子功能化的 WS2 纳米管，用于 PTT。用 CAN-mag 纳米颗粒对纳米管进行功能化，形成磁性纳米复合材料。当用两种类型的癌细胞进行体外测试时，与非功能化纳米管相比，功能化纳米管表现出更好的 PTT 活性，以及减少的聚集和添加第二步功能的能力。这里通过将两种聚合物接枝到纳米复合材料表面来证明这种能力，并且其他功能可以是额外的癌症治疗剂以实现增加的治疗活性。
Nanostructures of transition-metal dichalcogenides (TMDC) have raised scientific interest in the last few decades. Tungsten disulfide (WS2) nanotubes and nanoparticles are among the most extensively studied members in this group, and are used for, e.g., polymer reinforcement, lubrication and electronic devices. Their biocompatibility and low toxicity make them suitable for medical and biological applications. One potential application is photothermal therapy (PTT), a method for the targeted treatment of cancer, in which a light-responsive material is irradiated with a laser in the near-infrared range. In the current article we present WS2 nanotubes functionalized with previously reported ceric ammonium nitrate-maghemite (CAN-mag) nanoparticles, used for PTT. Functionalization of the nanotubes with CAN-mag nanoparticles resulted in a magnetic nanocomposite. When tested in vitro with two types of cancer cells, the functionalized nanotubes showed a better PTT activity compared to non-functionalized nanotubes, as well as reduced aggregation and the ability to add a second-step functionality. This ability is demonstrated here with two polymers grafted onto the nanocomposite surface, and other functionalities could be additional cancer therapy agents for achieving increased therapeutic activity.