IL-9 expression contributes to the cellular composition in Hodgkin lymphoma
IL-9 expression contributes to the cellular composition in Hodgkin lymphoma
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DOI：
10.1111/j.1600-0609.2005.00613.x
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发表时间：
2006-04-01
影响因子：
3.1
通讯作者：
Molin, D
中科院分区：
文献类型：
--
作者：
Glimelius, I;Edström, A;Molin, D
目的：霍奇金淋巴瘤 (HL) 肿瘤中存在大量肥大细胞或嗜酸性粒细胞都被描述为负面预后因素。与 HL 相关的一种细胞因子是白细胞介素 9 (IL-9)，已知它会影响肥大细胞和嗜酸性粒细胞。本研究的目的是探讨 HL 肿瘤中 IL-9 的表达是否与这些炎症细胞的存在相关。方法：在 131 例 HL 活组织检查中，进行了 IL-9 和 IL-9 受体 (IL-9R) 的免疫染色。先前对相同材料进行了肥大细胞和嗜酸性粒细胞染色。这些数据与所有患者的临床和生存数据相关。结果：53%的病例肿瘤细胞胞质中IL-9呈阳性，19%的病例呈IL-9R阳性。 IL-9阳性患者在诊断时肿瘤中有更多的嗜酸性粒细胞（P = 0.002）和肥大细胞（P = 0.02），更常见的结节性硬化组织学（P < 0.0001），更高的白细胞计数（P = 0.006）和更高的红细胞沉降率（P = 0.003）。结论：IL-9的表达与HL的组织学、临床表现以及嗜酸性粒细胞和肥大细胞的存在有关。这些结果表明IL-9是HL细胞因子网络和炎症浸润的重要组成部分。
Objectives: The presence of numerous mast cells or eosinophils in Hodgkin lymphoma (HL) tumours have both been described as negative prognostic factors. One cytokine related to HL is interleukin-9 (IL-9) and it is known to affect both mast cells and eosinophils. The aim of this study was to explore if the expression of IL-9 correlates to the presence of these inflammatory cells in HL tumours. Methods: In 131 HL biopsies, immunostainings for IL-9 and IL-9 receptor (IL-9R) were performed. The same material was previously stained for mast cells and eosinophils. These data were correlated to clinical and survival data from all patients. Results: Fifty-three percent of cases were positive for IL-9 and 19% were positive for IL-9R in the cytoplasm of the tumour cells. The IL-9 positive patients had more eosinophils (P = 0.002) and mast cells (P = 0.02) in their tumours, more often a nodular sclerosis histology (P < 0.0001), a higher white-blood-cell count (P = 0.006) and a higher erythrocyte sedimentation rate (P = 0.003) at the time of diagnosis. Conclusions: IL-9 expression is related to the histology, clinical picture and the presence of eosinophils and mast cells in HL. These results indicate that IL-9 is an important part of the cytokine network and inflammatory infiltrate in HL.