The burden attributable to mental and substance use disorders as risk factors for suicide: findings from the Global Burden of Disease Study 2010.
The burden attributable to mental and substance use disorders as risk factors for suicide: findings from the Global Burden of Disease Study 2010.
复制标题
DOI：
10.1371/journal.pone.0091936
复制
发表时间：
2014
期刊：
影响因子：
3.7
通讯作者：
Whiteford HA
中科院分区：
文献类型：
--
作者：
Ferrari AJ;Norman RE;Freedman G;Baxter AJ;Pirkis JE;Harris MG;Page A;Carnahan E;Degenhardt L;Vos T;Whiteford HA
《2010年全球疾病负担研究》(GBD 2010)以残疾调整寿命年(DALY)衡量，将精神和物质使用障碍列为2010年造成负担的第五大因素。这一估计是不完整的，因为它排除了2010年《GBD》S相互排斥的疾病和伤害清单中其他地方记录的自杀风险增加造成的负担。在这里，我们估计自杀DALY可归因于精神和物质使用障碍。精神和物质使用障碍所致自杀的相对风险估计和每种疾病的全球流行率被用来估计人群归因分数。这些数据根据精神和物质使用障碍导致的自杀比例与其他原因相比的全球差异进行了调整，然后乘以2010年GBD报告的自杀DALY，以估计可归因性DALY(具有95%的不确定性)。在2010年分配给自杀的3620万(2650万-4430万)DALY中，精神和物质使用障碍造成了2250万(1480万-2980万)。自杀DALY以抑郁为主(46.1%(28.0%~60.8%))，神经性厌食症最低(0.2%(0.02%~0.5%))。DALY发生在整个寿命过程中，东欧和亚洲发现的比例最大，男性年龄在20-30岁之间。将可归因性自杀DALY纳入全球DALY将使精神和物质使用障碍的总体负担(作为直接原因在2010年被分配给他们)从全球DALY的7.4%(6.2%-8.6%)增加到8.3%(7.1%-9.6%)，并将全球排名从第五大负担原因改为第三大负担原因。捕捉到可归因于精神和物质使用障碍的自杀负担可以更准确地估计负担。需要更多地考虑针对有精神和物质使用障碍或有精神和物质使用障碍风险的人群的干预措施，以此作为预防自杀的有效战略。
The Global Burden of Disease Study 2010 (GBD 2010) identified mental and substance use disorders as the 5th leading contributor of burden in 2010, measured by disability adjusted life years (DALYs). This estimate was incomplete as it excluded burden resulting from the increased risk of suicide captured elsewhere in GBD 2010's mutually exclusive list of diseases and injuries. Here, we estimate suicide DALYs attributable to mental and substance use disorders. Relative-risk estimates of suicide due to mental and substance use disorders and the global prevalence of each disorder were used to estimate population attributable fractions. These were adjusted for global differences in the proportion of suicide due to mental and substance use disorders compared to other causes then multiplied by suicide DALYs reported in GBD 2010 to estimate attributable DALYs (with 95% uncertainty). Mental and substance use disorders were responsible for 22.5 million (14.8–29.8 million) of the 36.2 million (26.5–44.3 million) DALYs allocated to suicide in 2010. Depression was responsible for the largest proportion of suicide DALYs (46.1% (28.0%–60.8%)) and anorexia nervosa the lowest (0.2% (0.02%–0.5%)). DALYs occurred throughout the lifespan, with the largest proportion found in Eastern Europe and Asia, and males aged 20–30 years. The inclusion of attributable suicide DALYs would have increased the overall burden of mental and substance use disorders (assigned to them in GBD 2010 as a direct cause) from 7.4% (6.2%–8.6%) to 8.3% (7.1%–9.6%) of global DALYs, and would have changed the global ranking from 5th to 3rd leading cause of burden. Capturing the suicide burden attributable to mental and substance use disorders allows for more accurate estimates of burden. More consideration needs to be given to interventions targeted to populations with, or at risk for, mental and substance use disorders as an effective strategy for suicide prevention.
登录
查看更多内容
影响因子：
168.9
作者：
Degenhardt, Louisa;Whiteford, Harvey A.;Vos, Theo
通讯作者：
Vos, Theo
影响因子：
4.4
作者：
Arsenault-Lapierre, Genevieve;Kim, Caroline;Turecki, Gustavo
通讯作者：
Turecki, Gustavo
影响因子：
3.3
作者：
Haagsma JA;van Beeck EF;Polinder S;Toet H;Panneman M;Bonsel GJ
通讯作者：
Bonsel GJ
影响因子：
5.4
作者：
Doi, Suhail A. R.;Thalib, Lukman
通讯作者：
Thalib, Lukman
影响因子：
6.9
作者：
Conner, KR;Phillips, MR;Yang, GH
通讯作者：
Yang, GH