Clinicopathological significance of tumor nest configuration in patients with esophageal squamous coil carcinoma
Clinicopathological significance of tumor nest configuration in patients with esophageal squamous coil carcinoma
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DOI：
10.1002/1097-0142(20010315)91:6
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发表时间：
2001-03-15
期刊：
影响因子：
6.2
通讯作者：
Hirohashi, S
中科院分区：
文献类型：
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作者：
Nakanishi, Y;Ochiai, A;Hirohashi, S
背景：肿瘤与间质的相互作用是肿瘤侵袭和转移的重要介质。方法：对159例晚期食管鳞状细胞癌（ESCC）患者的肿瘤巢形态及周围间质的临床病理意义进行研究。显微镜下将肿瘤分为两种类型。A型肿瘤具有椭圆形或片状肿瘤巢（>80%的肿瘤区域显示这些特征）。B型肿瘤呈星状或散在小肿瘤巢（肿瘤面积> 20%）。结果：159例肿瘤中，A型38例（24%），B型121例（76%）。B型肿瘤浸润深度深，淋巴管浸润和淋巴结转移多，成纤维细胞间质活跃，炎性细胞浸润少（P
BACKGROUND, Cancer-stromal interactions are an important mediator of cancer invasion and metastasis.METHODS, The authors investigated the clinicopathological significance of tumor nest configuration and the surrounding stroma in 159 patients with advanced esophageal squamous cell carcinoma (ESCC). The tumors were classified microscopically into two types. Type A tumors had oval-shaped or sheet-like tumor nests (with >80% of the tumor area showing these features). Type B tumors had asteroid-shaped or scattered small tumor nests (with > 20% of the tumor area showing these features).RESULTS, Of the 159 tumors examined, 38 (24%) were type A and 121 (76%) were type B. Type B tumors had a significantly deeper invasion depth, more frequent lymphatic permeation and lymph node metastasis, more prominent active fibroblastic stroma, and less frequent inflammatory cell infiltration (P