Facile synthesis of polymer-enveloped ultrasmall superparamagnetic iron oxide for magnetic resonance imaging
Facile synthesis of polymer-enveloped ultrasmall superparamagnetic iron oxide for magnetic resonance imaging
复制标题
DOI：
10.1088/0957-4484/18/13/135608
复制
发表时间：
2007-04-04
期刊：
影响因子：
3.5
通讯作者：
Yao, Side
中科院分区：
文献类型：
--
作者：
Hong, Jun;Xu, Dongmei;Yao, Side
基于磁铁矿核的合成聚合物的超质超磁铁（USPIO）通过易于光化的原位原位聚合合成。提出了光化学原位聚合的可能机制。通过透射电子显微镜（TEM），光相关光谱（PC），傅立叶变换红外光谱（FT-IR），热重仪（TG）分析和振动采样磁力表（VSM）测量表征，获得的聚合物开发的UPSIO的特征是。详细评估了磁共振成像（MRI）对比剂等特性，诸如超大粒径，亲水性，强磁化和表面特性。最终基于USPIO的MRI对比剂在分子MR跟踪，MR免疫成像，细胞跟踪和靶向细胞内高温等方面具有相当大的希望。
Ultrasmall superparamagnetic iron oxide ( USPIO) with synthetic polymer, based on magnetite core, was synthesized via facile photochemical in situ polymerization. A possible mechanism of photochemical in situ polymerization was proposed. The obtained polymer-enveloped UPSIO was characterized by transmission electron microscopy (TEM), photo-correlation spectroscopy (PCS), Fourier transform infrared spectroscopy (FT-IR), thermogravimetric (TG) analysis and vibrating sampling magnetometer (VSM) measurement. Properties such as ultrasmall particle size, hydrophilicity, strong magnetization and surface characteristics, which are desirable for magnetic resonance imaging (MRI) contrast agents, were evaluated in detail. The resultant USPIO-based MRI contrast agent holds considerable promise in molecular MR tracking, MR immune imaging, cell tracking and targeted intracellular hyperthermia, etc.