Triggering of Ca2+ signals by NAADP-gated two-pore channels: a role for membrane contact sites?
Triggering of Ca2+ signals by NAADP-gated two-pore channels: a role for membrane contact sites?
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DOI：
10.1042/bst20110693
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发表时间：
2012-02-01
影响因子：
3.9
通讯作者：
Brailoiu, Eugen
中科院分区：
文献类型：
--
作者：
Patel, Sandip;Brailoiu, Eugen
NAADP（nicotinic acid-adenine dinucleotide phosphate）是一种有效的钙动员信使，参与许多钙依赖性细胞过程。这是非常不寻常的，因为它似乎触发钙从酸性细胞器，如溶酶体释放。这些信号通常被位于内质网中的原型Ca 2+通道放大。最近的研究集中在TPC（双孔通道），其定位于内溶酶体系统作为NAADP介导其作用的可能的主要靶点。当TPC被引导远离内溶酶体系统时，TPC和内质网Ca 2+通道之间的“聊天”被破坏。这表明，细胞内的Ca 2+释放通道可能是密切apposed，可能在特定的膜接触位点之间的酸性细胞器和内质网。
NAADP (nicotinic acid-adenine dinucleotide phosphate) is a potent Ca2+ -mobilizing messenger implicated in many Ca2+ -dependent cellular processes. It is highly unusual in that it appears to trigger Ca2+ release from acidic organelles such as lysosomes. These signals are often amplified by archetypal Ca2+ channels located in the endoplasmic reticulum. Recent studies have converged on the TPCs (two-pore channels) which localize to the endolysosomal system as the likely primary targets through which NAADP mediates its effects. 'Chatter' between TPCs and endoplasmic reticulum Ca2+ channels is disrupted when TPCs are directed away from the endolysosomal system. This suggests that intracellular Ca2+ release channels may be closely apposed, possibly at specific membrane contact sites between acidic organelles and the endoplasmic reticulum.