C-type lectin receptor-mediated immune recognition and response of the microbiota in the gut.
C-type lectin receptor-mediated immune recognition and response of the microbiota in the gut.
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DOI：
10.1093/gastro/goz028
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发表时间：
2019
影响因子：
3.6
通讯作者：
Wang T
中科院分区：
文献类型：
--
作者：
Li T;Liu L;Hou Y;Shen S;Wang T
C-type lectin receptors (CLRs) are powerful pattern-recognition receptors that discern ‘self’ and ‘non-self’ in our body and.protect us from invasive pathogens by mediating immune recognition and response. The gastrointestinal tract is very.important for the maintenance of homeostasis; it is the largest shelter for the billions of microorganisms in the body and.CLRs play a crucial regulatory role in this system. This study focuses on several CLRs, including Dectin-1, Dectin-2, Dectin-3.and Mincle. We summarize the roles of CLRs in maintaining gastrointestinal immune-system homeostasis, especially their.functions in mediating immune recognition and responses in the gut, discuss their relationships to some diseases, highlight.the significance of CLR-mediated sensing of microbial and non-microbial compounds in the gut immune system and.identify new therapeutic targets.
