Comparison of (18)F-FDG PET/CT and (99 m)Tc-MDP bone scintigraphy for detection of bone metastasis in osteosarcoma
Comparison of (18)F-FDG PET/CT and (99 m)Tc-MDP bone scintigraphy for detection of bone metastasis in osteosarcoma
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DOI：
10.1007/s00256-013-1714-4
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发表时间：
2013-12-01
影响因子：
2.1
通讯作者：
Lim, Sang Moo
中科院分区：
文献类型：
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作者：
Byun, Byung Hyun;Kong, Chang-Bae;Lim, Sang Moo
我们比较了（18）F-氟脱氧葡萄糖正电子发射断层扫描/计算机断层扫描（PET/CT）和（99 m）Tc-亚甲基二膦酸盐骨显像（BS）在骨肉瘤骨转移检测中的诊断性能。我们回顾性分析了206例接受手术和化疗以及至少一对PET/CT和BS扫描（定义为检查）的II-IV期骨肉瘤患者。PET/CT和BS图像分别解释。当分析PET/CT和BS组合（PET/CT+BS）的诊断率时，如果PET/CT或BS评分为阳性，则认为检查为阳性。最后的诊断是从组织学结果或临床随访影像学研究至少6个月。计算PET/CT、BS及其组合的诊断性能，在206例患者的833次检查中，38例患者的55个101个病灶被证实为骨转移瘤。在基于检查的分析中，PET/CT的灵敏度、特异性和诊断准确性分别为95%、98%和98%; BS分别为76%、97%和96%; PET/CT+BS分别为100%、96%和97%。基于病灶的分析表明，PET/CT+BS的敏感性（100%）显著高于PET/CT（92%）或BS（74%）单独使用。BS检测到生长板区域中的骨转移显著少于生长板区域外（22%对77%）JET/CT对于诊断骨肉瘤中的骨转移比BS更敏感和准确。PET/CT和BS的联合使用提高了灵敏度。
We compared the diagnostic performance of (18)F-fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) and (99 m)Tc-methylene diphosphonate bone scintigraphy (BS) for the detection of bone metastasis in osteosarcoma.We retrospectively reviewed 206 patients with stage II-IV osteosarcoma treated with surgery and chemotherapy as well as at least one paired PET/CT and BS scan (defined as an examination). PET/CT and BS images were interpreted separately. When analyzing the diagnostic yield of a combination of PET/CT and BS (PET/CT+BS), an examination was considered positive if either PET/CT or BS scored positive. The final diagnosis was obtained from histological findings or clinical follow-up with imaging studies for at least 6 months. Diagnostic performances of PET/CT, BS, and their combinations were calculated.Out of 833 examinations in 206 patients, 55 with 101 lesions in 38 patients were confirmed as bone metastases. The sensitivity, specificity, and diagnostic accuracy were 95, 98, and 98 %, respectively, for PET/CT; 76, 97, and 96 %, respectively, for BS; and 100, 96, and 97 %, respectively, for PET/CT+BS in an examination-based analysis. Lesion-based analysis demonstrated that the sensitivity of PET/CT+BS (100 %) was significantly higher than that of PET/CT (92 %) or BS (74 %) alone. BS detected significantly less bone metastases in the growth plate region than outside the growth plate region (22 vs. 77 %).PET/CT is more sensitive and accurate than BS for diagnosing bone metastases in osteosarcoma. The combined use of PET/CT and BS improves sensitivity.