Rhodium-Catalyzed/Copper-Mediated Selective C2 Alkynylation of Indoles and C1 Alkynylation of Carbazoles with γ-Substituted tert-Propargyl Alcohols
Rhodium-Catalyzed/Copper-Mediated Selective C2 Alkynylation of Indoles and C1 Alkynylation of Carbazoles with γ-Substituted tert-Propargyl Alcohols
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DOI：
10.1002/cctc.201600218
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发表时间：
2016-06-21
期刊：
影响因子：
4.5
通讯作者：
Wen, Ting-Bin
中科院分区：
文献类型：
--
作者：
Li, Ting;Wang, Zhen;Wen, Ting-Bin
A novel rhodium-catalyzed/copper-mediated C2-selective C-H alkynylation of indoles using -substituted tert-propargyl alcohols as the alkynylating reagent and a removable 6-methylpyridin-2-yl as the directing group has been developed, which provides a viable pathway for direct C2-selective alkynylation of indoles. Moreover, this strategy could be extended to the C-H alkynylation of carbazoles at the C1 position.
