Synthesis of 1,3-diol synthons from epoxy aromatic precursors: an approach to the construction of polyacetate-derived natural products
Synthesis of 1,3-diol synthons from epoxy aromatic precursors: an approach to the construction of polyacetate-derived natural products
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DOI：
10.1021/jo00002a048
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发表时间：
1991
影响因子：
3.6
通讯作者：
D. A. Evans;J. Gauchet-Prunet;E. Carreira;A. Charette
中科院分区：
文献类型：
--
作者：
D. A. Evans;J. Gauchet-Prunet;E. Carreira;A. Charette
聚乙酸酯衍生的天然产物（例如苔藓抑素 1 和两性霉素 B）中立体规整多元醇亚基的鉴定导致了六碳和七碳 1, 3-二醇片段的高产率和立体选择性的聚合合成。该计划依赖于肉桂醇的对映选择性不对称环氧化/动力学拆分以及使用间位取代的茴香基环作为掩蔽/3-酮酯合成子。桦木还原
The identification of stereoregular polyol subunits within polyacetate-derived natural products such as bryostatin 1 and amphotericin B has led to the convergent synthesis of six-and seven-carbon 1, 3-diol fragments in high yields and stereoselectivities. This plan relies upon the enantioselective asymmetric epoxidation/kinetic resolution of cinnamyl alcohols and the use of meta-substituted anisyl rings as masked/3-keto ester synthons. Birch reduction