Muscle Lipid Metabolism: Role of Lipid Droplets and Perilipins.
Muscle Lipid Metabolism: Role of Lipid Droplets and Perilipins.
复制标题
DOI：
10.1155/2017/1789395
复制
发表时间：
2017
影响因子：
4.3
通讯作者：
Espinosa A
中科院分区：
文献类型：
--
作者：
Morales PE;Bucarey JL;Espinosa A
骨骼肌是机体碳水化合物和脂肪代谢的主要调节器之一，因此，它对葡萄糖和脂肪酸(FA)供应的变化非常敏感。骨骼肌是一种极其复杂的组织：它的新陈代谢能力取决于它所组成的纤维的类型以及它所经历的刺激水平，如急性或慢性收缩。肥胖通常与FA水平升高有关，这会导致有毒脂质中间体的积累，氧化应激，以及骨骼纤维的自噬。这种脂毒性是导致胰岛素抵抗(IR)的最常见原因之一。在这种情况下，通过特定的脂滴--Perilipin(Plin)蛋白家族的作用，在特定的细胞隔室中“分离”某些脂类，被认为是一种救生员的补偿策略。在这篇综述中，我们总结了骨骼肌内脂质动员和代谢的细胞机制，重点是脂滴的功能，Plin蛋白家族，以及这些实体在运动、肥胖和IR条件下是如何被改变的。
Skeletal muscle is one of the main regulators of carbohydrate and lipid metabolism in our organism, and therefore, it is highly susceptible to changes in glucose and fatty acid (FA) availability. Skeletal muscle is an extremely complex tissue: its metabolic capacity depends on the type of fibers it is made up of and the level of stimulation it undergoes, such as acute or chronic contraction. Obesity is often associated with increased FA levels, which leads to the accumulation of toxic lipid intermediates, oxidative stress, and autophagy in skeletal fibers. This lipotoxicity is one of the most common causes of insulin resistance (IR). In this scenario, the “isolation” of certain lipids in specific cell compartments, through the action of the specific lipid droplet, perilipin (PLIN) family of proteins, is conceived as a lifeguard compensatory strategy. In this review, we summarize the cellular mechanism underlying lipid mobilization and metabolism inside skeletal muscle, focusing on the function of lipid droplets, the PLIN family of proteins, and how these entities are modified in exercise, obesity, and IR conditions.