The Importance of LAT in the Activation, Homeostasis, and Regulatory Function of T Cells
The Importance of LAT in the Activation, Homeostasis, and Regulatory Function of T Cells
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DOI：
10.1074/jbc.m110.145052
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发表时间：
2010-11-12
影响因子：
4.8
通讯作者：
Zhang, Weiguo
中科院分区：
文献类型：
--
作者：
Shen, Shudan;Chuck, Mariana I.;Zhang, Weiguo
LAT (linker for activation of T cells) is a transmembrane adaptor protein that plays an essential role in TCR-mediated signaling and thymocyte development. Because LAT-deficient mice have an early block in thymocyte development, we utilized an inducible system to delete LAT in primary T cells to study LAT function in T cell activation, homeostasis, and survival. Deletion of LAT caused primary T cells to become unresponsive to stimulation from the TCR and impaired T cell homeostatic proliferation and long term survival. Furthermore, deletion of LAT led to reduced expression of Foxp3, CTLA-4, and CD25 in T-reg cells and impaired their function. Consequently, mice with LAT deleted developed a lymphoproliferative syndrome similar to that in LATY136F mice, although less severe. Our data implicate that LAT has positive and negative roles in the regulation of mature T cells.
