A Comprehensive Study of Genic Variation in Natural Populations of Drosophila melanogaster. I. Estimates of Gene Flow from Rare Alleles.
A Comprehensive Study of Genic Variation in Natural Populations of Drosophila melanogaster. I. Estimates of Gene Flow from Rare Alleles.
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果蝇自然种群基因变异的综合研究。
DOI：
10.1093/genetics/115.2.313
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发表时间：
1987
期刊：
影响因子：
3.3
通讯作者：
L. Rhomberg
中科院分区：
文献类型：
--
作者：
Rama S. Singh;L. Rhomberg
为了评估黑腹果蝇自然种群分子变异的进化意义，我们已经开始了一项全面的遗传变异研究计划，利用相对大量的基因-蛋白位点和来自世界各地不同地理位置的一系列种群。在这第一份报告中，我们基于117个稀有等位基因的空间分布，对世界上15个黑腹龙种群的基因流进行了估计。Nm（人口之间每代交换的移民数量）的估计范围从东亚人口（台湾、越南和澳大利亚）的1.09到北美西海岸人口的2.66。在相隔数百甚至数千英里的地理种群中，这些估计表明，邻近种群之间的基因流动相当广泛。这意味着，对于选择性中性基因，我们应该期望邻近种群之间的差异很小。对8个西海岸黑腹果蝇种群（地理位置与伪腹果蝇相似）的调查表明，尽管存在广泛的基因流动，但黑腹果蝇种群的地理分化程度远高于伪腹果蝇种群。由此我们得出结论，迁移与自然选择的结合，而不是迁移本身，是造成假木桐分子多态性地理一致性的原因。
In order to assess the evolutionary significance of molecular variation in natural populations of Drosophila melanogaster, we have started a comprehensive genetic variation study program employing a relatively large number of gene-protein loci and an array of populations obtained from various geographic locations throughout the world. In this first report we provide estimates of gene flow based on the spatial distributions of rare alleles at 117 gene loci in 15 worldwide populations of D. melanogaster . Estimates of Nm (number of migrants exchanged per generation among populations) range from 1.09 in East-Asian populations (Taiwan, Vietnam and Australia) to 2.66 in West-Coast populations of North America. These estimates, among geographic populations separated by hundreds or even thousands of miles, suggest that gene flow among neighboring populations of D. melanogaster is quite extensive. This means that, for selectively neutral genes, we should expect little differentiation among neighboring populations. A survey of eight West-Coast populations of D. melanogaster (geographically comparable to Drosophila pseudoobscura) showed that in spite of extensive gene flow, populations of D. melanogaster show much more geographic differentiation than comparable populations of D. pseudoobscura. From this we conclude that migration in combination with natural selection rather than migration alone is responsible for the geographic uniformity of molecular polymorphisms in D. pseudoobscura.
果蝇的基因流和分子多态性的地理分布。
影响因子：
3.3
作者：
Jones,JS;Bryant,SH;Lewontin,RC;Moore,JA;Prout,T
通讯作者：
Prout,T