Prediction of protein-protein interactions:: the CAPRI experiment, its evaluation and implications
Prediction of protein-protein interactions:: the CAPRI experiment, its evaluation and implications
复制标题
DOI：
10.1016/j.sbi.2004.02.003
复制
发表时间：
2004-04-01
影响因子：
6.8
通讯作者：
Méndez, R
中科院分区：
文献类型：
--
作者：
Wodak, SJ;Méndez, R
随着人们对蛋白质相互作用的兴趣日益增加，从序列和结构信息预测这些相互作用已经成为一个蓬勃发展的活动。卡普里是一个用于评估蛋白质-蛋白质相互作用盲态预测的社区范围实验，在促进对接程序的进展方面发挥着重要作用。与此同时，新的方法正在推导出用于预测可能相互作用的蛋白质区域，并从序列和结构数据中表征推定的分子间接触。与对接程序，这些方法提供了一个综合的计算方法，应该是一个有价值的补充，基因组规模的蛋白质-蛋白质相互作用的实验研究。
Given the increasing interest in protein-protein interactions, the prediction of these interactions from sequence and structural information has become a booming activity. CAPRI, the community-wide experiment for assessing blind predictions of protein-protein interactions, is playing an important role in fostering progress in docking procedures. At the same time, novel methods are being derived for predicting regions of a protein that are likely to interact and for characterizing putative intermolecular contacts from sequence and structural data. Together with docking procedures, these methods provide an integrated computational approach that should be a valuable complement to genome-scale experimental studies of protein-protein interactions.