LASP-1 (MLN-50) DEFINES A NEW LIM PROTEIN SUBFAMILY CHARACTERIZED BY THE ASSOCIATION OF LIM AND SH3 DOMAINS
LASP-1 (MLN-50) DEFINES A NEW LIM PROTEIN SUBFAMILY CHARACTERIZED BY THE ASSOCIATION OF LIM AND SH3 DOMAINS
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DOI：
10.1016/0014-5793(95)01040-l
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发表时间：
1995-10-16
期刊：
影响因子：
3.5
通讯作者：
RIO, MC
中科院分区：
文献类型：
--
作者：
TOMASETTO, C;MOOGLUTZ, C;RIO, MC
MLN 50以前在乳腺癌转移的cDNA文库中鉴定。在这项研究中，我们发现MLN 50在正常组织中以基础水平表达，在8%的人乳腺癌中过度表达，最常见的是与c-erbB-2一起，MLN 50 cDNA编码261个残基的推定蛋白，Lasp-1（LIM和SH 3蛋白），因为它在蛋白的氨基-和C-末端部分含有LIM基序和Src同源区3（SH 3）的结构域，分别因此，Lasp-1定义了一个新的LIM蛋白亚家族。
MLN 50 was previously identified in a cDNA library of breast cancer metastasis. In this study, we show that MLN 50, which is expressed at a basal level in normal tissues, is overexpressed in 8% of human breast carcinomas most often together with c-erbB-2, MLN 50 cDNA encodes a putative protein of 261 residues, named Lasp-1 (LIM and SH3 protein) since it contains a LIM motif and a domain of Src homology region 3 (SH3) at the amino- and the C-terminal parts of the protein, respectively. Thus, Lasp-1 defines a new LIM protein subfamily.