An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents
An eco-friendly water mediated synthesis of 1,2,3-triazolyl-2-aminopyrimidine hybrids as highly potent anti-bacterial agents
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DOI：
10.1016/j.cclet.2013.12.017
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发表时间：
2014-03-01
影响因子：
9.1
通讯作者：
Shanmugaiah, Vellasamy
中科院分区：
文献类型：
--
作者：
Nagarajan, Sangaraiah;Shanmugavelan, Poovan;Shanmugaiah, Vellasamy
首次在绿色溶剂水溶液中合成了1，2，3-三唑并2-氨基嘧啶类化合物。当针对三种人类病原体即金黄色葡萄球菌、铜绿假单胞菌和肺炎克雷伯菌筛选时，杂合分子表现出显著的抗菌活性。与市售药物四环素相比，它们中的一些同样有效，一些更有效。(C)2013年Alagusundaram Ponnuswamy和Vellasamy Shanmugaiah。Elsevier B. V.代表中国化学会出版。All rights reserved.
An elegant and efficient synthesis of novel 1,2,3-triazole fused 2-aminopyrimidine hybrids has been accomplished for the first time in the green solvent viz. water. The hybrid molecules exhibit significant anti-bacterial activity when screened against three human pathogens viz. Staphylococcus aureus, Pseudomonas aeruginosa and Klebsiella pneumoniae. In comparison to the commercially marketed drug tetracycline, some of them are equally potent and a few are more potent. (C) 2013 Alagusundaram Ponnuswamy and Vellasamy Shanmugaiah. Published by Elsevier B.V. on behalf of Chinese Chemical Society. All rights reserved.