HEMOPHILIC ARTHROPATHY - CURRENT CONCEPTS OF PATHOGENESIS AND MANAGEMENT
HEMOPHILIC ARTHROPATHY - CURRENT CONCEPTS OF PATHOGENESIS AND MANAGEMENT
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DOI：
10.2106/00004623-197759030-00001
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发表时间：
1977-01-01
影响因子：
5.3
通讯作者：
HILGARTNER, MW
中科院分区：
文献类型：
--
作者：
ARNOLD, WD;HILGARTNER, MW
凝血因子VIII和IX的实用浓缩物的开发彻底改变了血友病性关节病的治疗方法，以前血友病性关节病使血友病患者致残，并使他们生活在痛苦之中。骨科医生和血液科医生现在可以在扭转，控制和纠正血友病关节病方面取得相当大的成功。在这些关节中发现高水平的蛋白水解酶活性为关节病的炎症性质提供了解释，并为治疗提供了依据。家庭护理计划的进一步发展应减少血友病患者对医院的依赖。膝关节和肘关节成形术需要标准化和可靠的技术。进一步研究血友病性关节病的性质将阐明手术和可能的化学滑膜切除术在血友病治疗中的作用。这些病人的外科治疗很可能在临床中心普遍可行，而不仅仅是在少数几个目前活跃的血友病中心。
The development of practical concentrates of Factors VIII and IX has revolutionized the management of hemophilic arthropathy, which formerly crippled hemophiliacs and condemned them to a life of pain. The orthopedic surgeon and hematologist can now achieve considerable success in reversing, controlling and correcting hemophilic arthropathy. The finding of high levels of proteolytic enzyme activity in these joints offers an explanation for the inflammatory nature of the arthropathy and a rationale for the treatment outlined. Further development of home care programs should lessen the dependency of hemophiliacs on hospitals. Standardized and reliable techniques for knee and elbow arthroplasty are needed. Further investigation into the nature of hemophilic arthropathy will clarify the role of surgical and possibly chemical synovectomy in the management of hemophiliacs. It is likely that the surgical care of these patients will become feasible in clinical centers generally, rather than just in the few hemophilic centers now active.