Multi-functional Ultrasonic Micro-elastography Imaging System.
Multi-functional Ultrasonic Micro-elastography Imaging System.
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DOI：
10.1038/s41598-017-01210-8
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发表时间：
2017-04-27
影响因子：
4.6
通讯作者：
Zhou Q
中科院分区：
文献类型：
--
作者：
Qian X;Ma T;Yu M;Chen X;Shung KK;Zhou Q
在临床决策中，除了解剖信息外，软组织的生物力学特性可能为疾病诊断提供额外的线索。鉴于大多数疾病起源于微米大小的结构，需要一种精细分辨率（~100µm）和深穿透深度的弹性成像系统，能够提供生物力学特性的定性和定量测量。在这里，我们报告了一种新开发的多功能超声微弹性成像系统，其中实现了声辐射力脉冲成像（ARFI）和剪切波弹性成像（SWEI）。为此，分别使用4.5 MHz/40 MHz换能器作为激励源/检测源。通过模拟组织模型和离体鸡肝脏的2D/3D成像对该成像系统进行了测试。ARFI的横向/轴向弹性成像分辨率和视场分别为223.7±20.1/109.8±6.9µm和1.5 mm， SWEI为543.6±39.3/117.6±8.7µm和2 mm。这些结果表明，这种高分辨率弹性成像系统在微观水平上表征组织生物力学特性的潜力及其在临床实践中的转化潜力。
In clinical decision making, in addition to anatomical information, biomechanical properties of soft tissues may provide additional clues for disease diagnosis. Given the fact that most of diseases are originated from micron sized structures, an elastography imaging system of fine resolution (~100 µm) and deep penetration depth capable of providing both qualitative and quantitative measurements of biomechanical properties is desired. Here, we report a newly developed multi-functional ultrasonic micro-elastography imaging system in which acoustic radiation force impulse imaging (ARFI) and shear wave elasticity imaging (SWEI) are implemented. To accomplish this, the 4.5 MHz/40 MHz transducer were used as the excitation/detection source, respectively. The imaging system was tested with tissue-mimicking phantoms and an ex vivo chicken liver through 2D/3D imaging. The measured lateral/axial elastography resolution and field of view are 223.7 ± 20.1/109.8 ± 6.9 µm and 1.5 mm for ARFI, 543.6 ± 39.3/117.6 ± 8.7 µm and 2 mm for SWEI, respectively. These results demonstrate that the promising capability of this high resolution elastography imaging system for characterizing tissue biomechanical properties at microscale level and its translational potential into clinical practice.