Cancer and the Circadian Clock.
Cancer and the Circadian Clock.
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DOI：
10.1158/0008-5472.can-19-0566
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发表时间：
2019-08-01
期刊：
影响因子：
11.2
通讯作者：
Knudsen KE
中科院分区：
文献类型：
--
作者：
Shafi AA;Knudsen KE
生物钟是哺乳动物生理的主要调节器，调节着关键生物过程和行为的日常振荡。值得注意的是，昼夜节律紊乱最近被确定为癌症的一个独立风险因素，并被归类为致癌物。因此，必须辨别昼夜节律中断改变癌症风险的基本机制。本文回顾的最新数据表明，昼夜节律调节功能在癌症的几个特征中起着关键作用，包括控制细胞增殖、细胞死亡、DNA修复和代谢改变。深入了解昼夜节律与癌症的相互作用，有助于开发癌症拦截、预防和管理的新策略。
The circadian clock is a master regulator of mammalian physiology, regulating daily oscillations of crucial biological processes and behaviors. Notably, circadian disruption has recently been identified as an independent risk factor for cancer and classified as a carcinogen. As such, it is imperative to discern the underpinning mechanisms by which circadian disruption alters cancer risk. Emergent data, reviewed herein, demonstrate that circadian regulatory functions play critical roles in several hallmarks of cancer, including control of cell proliferation, cell death, DNA repair, and metabolic alteration. Developing a deeper understanding of circadian-cancer regulation cross-talk holds promise for developing new strategies for cancer interception, prevention, and management.