Regional Regulation of Filiform Tongue Papillae Development by Ikkα/Irf6
Regional Regulation of Filiform Tongue Papillae Development by Ikkα/Irf6
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DOI：
10.1002/dvdy.24427
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发表时间：
2016-09-01
影响因子：
2.5
通讯作者：
Ohazama, Atsushi
中科院分区：
文献类型：
--
作者：
Kawasaki, Maiko;Kawasaki, Katsushige;Ohazama, Atsushi
背景资料：非味觉丝状乳头在帮助抓握食物、将食物吸入食道、清洁口腔和传播唾液方面起着关键作用。然而，丝状舌乳头发育的分子机制尚未完全了解。结果如下：我们发现Ikk α和Irf 6在发育中的舌上皮细胞中表达，并在此描述了这些基因突变的小鼠的特定舌异常，表明Ikk α和Irf 6在丝状乳头发育中的作用。Ikk α和Irf 6突变体舌在中线处显示异位垂直上皮，而突变体舌的侧面粘附于口腔粘膜。异位正中垂直上皮和粘附上皮均表现出丝状舌乳头的存在，而正中垂直上皮和粘附舌之间的上皮则表现出丝状舌乳头的缺失。丝状乳头发育的时间被认为是略有不同的中线和外侧区域的野生型舌。结论：因此，丝状乳头通过不同的分子机制在舌背区域之间在内外轴上发育，其中一些丝状乳头在Ikk α和Irf 6的控制下发育。发展动力学245：937-946，2016年。(C)2016 Wiley Periodicals，Inc.
Background: Non-gustatory filiform papillae play critical roles in helping to grip food, drawing food to the esophagus, cleaning the mouth, and spreading saliva. The molecular mechanisms of filiform tongue papillae development however are not fully understood. Results: We found Ikk alpha and Irf6 expression in developing tongue epithelium, and describe here specific tongue abnormalities in mice with mutation of these genes, indicating a role for Ikk alpha and Irf6 in filiform papillae development. Ikk alpha and Irf6 mutant tongues showed ectopic vertical epithelium at the midline, while lateral sides of mutant tongues adhered to the oral mucosa. Both the ectopic median vertical epithelium and adhered epithelium exhibited the presence of filiform tongue papillae, whereas epithelium between the median vertical epithelium and adhered tongue showed a loss of filiform tongue papillae. Timing of filiform papillae development was found to be slightly different between the midline and lateral regions of the wild-type tongue. Conclusions: Filiform papillae thus develop through distinct molecular mechanisms between the regions of tongue dorsum in the medio-lateral axis, with some filiform papillae developing under the control of Ikk alpha and Irf6. Developmental Dynamics 245: 937-946, 2016. (C) 2016 Wiley Periodicals, Inc.