Command and compensation in a neuromodulatory decision network.
Command and compensation in a neuromodulatory decision network.
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DOI：
10.1523/jneurosci.3707-11.2012
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发表时间：
2012-01-18
期刊：
影响因子：
--
通讯作者：
White BH
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文献类型：
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作者：
Luan H;Diao F;Peabody NC;White BH
调节行为选择的神经回路不仅必须权衡内部需求和环境环境，还必须选择和执行特定的行动，包括相关的内脏或神经内分泌功能。协调这些多个过程意味着相当复杂。因此，即使是支持简单行为决定的电路也仍然知之甚少。在这里，我们展示了成年果蝇对环境敏感的翅膀扩张决定是由一对具有命令样功能的神经调节神经元协调的。使用Split Gal4系统有针对性地抑制这些神经元，可以剥夺苍蝇在面对环境挑战时展开翅膀的能力，而刺激它们则通过协调激活运动和神经内分泌输出来推动扩张。这对神经元对翅膀扩张决定的仲裁和执行可能说明了神经调节神经元协调行为的一般策略。有趣的是，决策网络显示出一种行为可塑性，这种可塑性在缺乏类似命令的神经调节神经元功能的果蝇身上，在有利的环境条件下被揭示出来。这种苍蝇通常可以使用与野生动物和对照不同的运动程序来扩展它们的翅膀。这一补偿计划可能是一个祖先的、环境不敏感的计划的遗迹，用于扩张翅膀，在果蝇和其他环状苍蝇目前使用的环境适应性计划进化之前就存在了。
The neural circuits that mediate behavioral choices must not only weigh internal demands and environmental circumstances, but also select and implement specific actions, including associated visceral or neuroendocrine functions. Coordinating these multiple processes suggests considerable complexity. As a consequence, even circuits that support simple behavioral decisions remain poorly understood. Here we show that the environmentally-sensitive wing expansion decision of adult fruit flies is coordinated by a single pair of neuromodulatory neurons with command-like function. Targeted suppression of these neurons using the Split Gal4 system abrogates the fly's ability to expand its wings in the face of environmental challenges, while stimulating them forces expansion by coordinately activating both motor and neuroendocrine outputs. The arbitration and implementation of the wing expansion decision by this neuronal pair may illustrate a general strategy by which neuromodulatory neurons orchestrate behavior. Interestingly, the decision network shows a behavioral plasticity that is unmasked under conducive environmental conditions in flies lacking the function of the command-like neuromodulatory neurons. Such flies can often expand their wings using a motor program distinct from that of wildtype animals and controls. This compensatory program may be the vestige of an ancestral, environmentally-insensitive program used for wing expansion that existed prior to the evolution of the environmentally-adaptive program currently used by Drosophila and other cyclorrhaphan flies.