Chlorine and sodium chemical shift imaging during acute stroke in a rat model at 9.4 Tesla
Chlorine and sodium chemical shift imaging during acute stroke in a rat model at 9.4 Tesla
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DOI：
10.1007/s10334-013-0398-z
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发表时间：
2014-02-01
影响因子：
2.3
通讯作者：
Schad, Lothar R.
中科院分区：
文献类型：
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作者：
Baier, Sebastian;Kraemer, Philipp;Schad, Lothar R.
采用H-1线性谐振器和双调谐Na-23/Cl-35表面线圈组成的三共振线圈装置，研究了9.4特斯拉急性期大鼠脑卒中模型中Cl-35和Na-23的T(2)（*）和M(0)的演化。在脑卒中发作后1.5-7小时（n = 2）、发病后10天（n = 1）和健康对照大鼠身上，通过化学位移成像序列进行体内测量。测定时间分别为15 min （Na-23）和57 min （Cl-35）。发作后10天的松弛时间[T (2) (*) = 14.3 +/- A 1.8 ms （Na-23）和6.0 +/- A 1.3 ms (Cl-35)]与健康大鼠相比明显延长[T (2) (*) = 4.8 +/- A 0.6 ms （Na-23）和2.1 +/- A 0.3 ms (Cl-35)]和急性期[T (2) (*) = 5.6 +/- A 0.2 ms （Na-23）和1.9 +/- A 0.1 ms (Cl-35)]。心肌梗死区M(0)的升高明显晚于钠。据我们所知，这是第一次在动物中风模型急性期进行质子、钠和氯的联合测量。
A triple-resonant coil setup with an H-1 linear resonator and a double-tuned Na-23/Cl-35 surface coil was used to study the evolution of T (2) (*) and M (0) for Cl-35 and Na-23 in a rat stroke model during the acute phase at 9.4 Tesla.In vivo measurements were performed 1.5-7 h after onset of stroke (n = 2), ten days after onset (n = 1) and on a healthy control rat by a chemical shift imaging sequence. Measurement times were 15 min (Na-23) and 57 min (Cl-35).The relaxation times ten days after onset [T (2) (*) = 14.3 +/- A 1.8 ms (Na-23) and 6.0 +/- A 1.3 ms (Cl-35)] are clearly prolonged in comparison to a healthy rat [T (2) (*) = 4.8 +/- A 0.6 ms (Na-23) and 2.1 +/- A 0.3 ms (Cl-35)] and the acute phase [T (2) (*) = 5.6 +/- A 0.2 ms (Na-23) and 1.9 +/- A 0.1 ms (Cl-35)].M (0) in the infarcted region clearly rises later and slower for chlorine than for sodium. To the best of our knowledge, these are the first combined proton, sodium, and chlorine measurements in an animal stroke model during the acute phase.