Divergent connectomic organization delineates genetic evolutionary traits in the human brain.
Divergent connectomic organization delineates genetic evolutionary traits in the human brain.
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DOI：
10.1038/s41598-021-99082-6
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发表时间：
2021-10-04
影响因子：
4.6
通讯作者：
Sepulcre J
中科院分区：
文献类型：
--
作者：
Bueichekú E;Gonzalez-de-Echavarri JM;Ortiz-Teran L;Montal V;d'Oleire Uquillas F;De Marcos L;Orwig W;Kim CM;Ortiz-Teran E;Basaia S;Diez I;Sepulcre J
人脑连接组学和遗传进化特征之间的关系仍然难以捉摸，因为在脑组织内结合复杂的关联存在固有的挑战。在这项研究中，见解提供了关于连接组学，基因表达和不同的进化途径之间的关系，从非人灵长类动物到人类。使用在体人脑静息状态数据，我们发现了两个共存的特质功能系统：分离网络，负责模块专业化，和整合网络，负责信息流。它们的拓扑结构近似于全脑基因表达（艾伦人脑图谱），并且共定位模式产生了与神经元投射相关的神经元通信功能是过度代表的细胞特征。使用dN/dS比率的同源物-直向同源物比较弥合了神经遗传学结果与生物学数据之间的差距，总结了智人谱系内已知的进化分歧途径。有证据表明，功能特化和信息流之间的串扰反映了大脑结构的假定生物学特性，例如轴突或树突过程等神经突细胞功能，假设通过正向选择在物种中选择性保守。这些发现扩展了我们对人类大脑功能的理解，并揭示了我们与猿类祖先之前未被探索的认知轨迹。
The relationship between human brain connectomics and genetic evolutionary traits remains elusive due to the inherent challenges in combining complex associations within cerebral tissue. In this study, insights are provided about the relationship between connectomics, gene expression and divergent evolutionary pathways from non-human primates to humans. Using in vivo human brain resting-state data, we detected two co-existing idiosyncratic functional systems: the segregation network, in charge of module specialization, and the integration network, responsible for information flow. Their topology was approximated to whole-brain genetic expression (Allen Human Brain Atlas) and the co-localization patterns yielded that neuron communication functionalities—linked to Neuron Projection—were overrepresented cell traits. Homologue-orthologue comparisons using dN/dS-ratios bridged the gap between neurogenetic outcomes and biological data, summarizing the known evolutionary divergent pathways within the Homo Sapiens lineage. Evidence suggests that a crosstalk between functional specialization and information flow reflects putative biological qualities of brain architecture, such as neurite cellular functions like axonal or dendrite processes, hypothesized to have been selectively conserved in the species through positive selection. These findings expand our understanding of human brain function and unveil aspects of our cognitive trajectory in relation to our simian ancestors previously left unexplored.
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DOI：
10.1177/1073858416667720
发表时间：
2017-10
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Bassett DS;Bullmore ET
通讯作者：
Bullmore ET
影响因子：
9.8
作者：
Holmes, Avram J.;Hollinshead, Marisa O.;O'Keefe, Timothy M.;Petrov, Victor I.;Fariello, Gabriele R.;Wald, Lawrence L.;Fischl, Bruce;Rosen, Bruce R.;Mair, Ross W.;Roffman, Joshua L.;Smoller, Jordan W.;Buckner, Randy L.
通讯作者：
Buckner, Randy L.
DOI：
10.1523/jneurosci.1929-08.2008
发表时间：
2008-09-10
期刊：
The Journal of neuroscience : the official journal of the Society for Neuroscience
影响因子：
--
作者：
Bassett DS;Bullmore E;Verchinski BA;Mattay VS;Weinberger DR;Meyer-Lindenberg A
通讯作者：
Meyer-Lindenberg A
遗传变化塑造了人脑。
影响因子：
11.8
作者：
Bae BI;Jayaraman D;Walsh CA
通讯作者：
Walsh CA
DOI：
10.1146/annurev-clinpsy-040510-143934
发表时间：
2011-01-01
影响因子：
18.4
作者：
Bullmore, Edward T.;Bassett, Danielle S.
通讯作者：
Bassett, Danielle S.