Maoecrystal V, cytotoxic diterpenoid with a novel C19 skeleton from Isodon eriocalyx (Dunn.) Hara
Maoecrystal V, cytotoxic diterpenoid with a novel C19 skeleton from Isodon eriocalyx (Dunn.) Hara
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DOI：
10.1021/ol0481535
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发表时间：
2004-11-11
期刊：
影响因子：
5.2
通讯作者：
Zheng, QT
中科院分区：
文献类型：
--
作者：
Li, SH;Wang, J;Zheng, QT
毛晶V(1)是从中草药香茶菜(Isodon Eriocalyx)叶中分离得到的一个新的C-19二萜化合物，具有独特的6，7-seco-6-nor-15(8-->；9)-abeo-5，8-epoxy-ent-kaurane骨架。其结构经核磁共振和质谱分析确证，并经单晶X-射线衍射法确证。化合物1对HeLa细胞有明显的抑制作用，其IC50=0.02mug/m L(顺铂：IC50=0.99 m u/m L)。
Maoecrystal V (1), a novel C-19 diterpenoid possessing a unique 6,7-seco-6-nor-15(8-->9)-abeo-5,8-epoxy-ent-kaurane skeleton, was isolated from the leaves of a Chinese medicinal herb, Isodon eriocalyx. Its structure was determined by comprehensive NMR and MS spectroscopic analysis and confirmed by single-crystal X-ray diffraction study. Compound 1 showed remarkable inhibitory activity toward HeLa cells with IC50 = 0.02 mug/mL (cis-platin: IC50 = 0.99 mug/mL).