INHIBITION OF ATHEROSCLEROSIS ASSOCIATED WITH REDUCTION OF ARTERIAL INTRAMURAL STRESS IN RABBITS
INHIBITION OF ATHEROSCLEROSIS ASSOCIATED WITH REDUCTION OF ARTERIAL INTRAMURAL STRESS IN RABBITS
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DOI：
10.1161/01.atv.8.4.410
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发表时间：
1988-07-01
期刊：
影响因子：
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通讯作者：
NOLAN, SP
中科院分区：
文献类型：
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作者：
THUBRIKAR, MJ;BAKER, JW;NOLAN, SP
动脉粥样硬化病变通常发生在动脉分支部位，这些部位也是由腔内压力产生的高动脉壁内应力的部位。我们研究了减少内应力对动脉粥样硬化病变发展的影响。我们暴露了5只兔的左肾动脉起源和另外5只兔的主动脉分叉，将平均动脉压降至35 ~ 45mmhg，并在分支周围灌注牙科丙烯酸液体形成刚性铸型。当家兔恢复正常，动脉压恢复正常时，铸型可以防止动脉扩张，从而维持较低的内应力。这些兔子加上2只未手术的，2只假手术的，2只在相似压力下放置硅橡胶模型的，4只在95毫米汞柱压力下放置模型的，给予7到11周富含2%胆固醇的饮食，然后检查它们的动脉。在所有家兔中，动脉粥样硬化病变发生在肋间动脉、腹腔动脉、肠系膜上动脉、双肾动脉和主动脉分叉处，但有几个明显的例外：铸型肾动脉起源处和铸型主动脉分叉处，当铸型在低压下放置时，没有病变发生。对左肾支和主动脉分叉区主动脉直径和厚度的测量，无论是否有铸型，表明没有明显的因铸型引起的主动脉腔狭窄或主动脉变薄。总之，抑制动脉粥样硬化病变的发展似乎与动脉壁内应激的减少有关。
Atherosclerotic lesions commonly develop at arterial branch sites, which are also the sites of high arterial intramural stress produced by intraluminal pressure. We investigated the effect of reduced intramural stress on the development of atherosclerotic lesions. We exposed the origin of the left renal artery in five rabbits and the aortic bifurcation in another five, lowered the mean arterial pressure to 35 to 45 mm Hg, and poured a dental acrylic liquid around the branch to form a rigid cast. When the rabbits recovered and the arterial pressure increased to normal, the casts prevented the arteries from expanding, thereby maintaining a low intramural stress. These rabbits plus two unoperated, two sham-operated, two with silicone rubber casts placed at similar pressures, and four with casts placed at 95 mm Hg pressure were given a 2% cholesterol-enriched diet for 7 to 11 weeks, and then their arteries were examined. In all rabbits, atherosclerosis lesions developed at the origins of the intercostal, celiac, superior mesenteric, and both renal arteries, and at the aortic bifurcation, with these notable exceptions: no lesions developed at the origins of casted renal arteries or at the casted aortic bifurcations when the cast was placed at a low pressure. Measurements of the diameter and thickness of the aorta in the left renal branch and aortic bifurcation areas, with and without the casts, indicated that there was no significant narrowing of the aortic lumen or thinning of the aorta due to the cast. In conclusion, the inhibition of the development of atherosclerosis lesions appears to be associated with the reduction of arterial intramural stress.