B-cell superantigens may play a role in B-cell development and selection in the young rabbit appendix
B-cell superantigens may play a role in B-cell development and selection in the young rabbit appendix
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DOI：
10.1006/cimm.1998.1288
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发表时间：
1998-05-01
影响因子：
4.3
通讯作者：
Mage, RG
中科院分区：
文献类型：
--
作者：
Pospisil, R;Mage, RG
In order to develop protective antibodies against a wide range of potentially infectious pathogens, the young rabbit must diversify a limited initial repertoire by somatic mechanisms (the high copy number primary repertoire). The majority of rabbit B cells produce heavy chain variable regions by rearranging the V(H)a allotype-encoding V(H)1 gene. Thus in normal rabbits the majority of serum immunoglobulins bear V(H)a allotype (due to V(H)1 FR1 and FR3 sequences). The young rabbit appendix is a site of diversification of rearranged V-H genes by gene-conversion-like and somatic hypermutation mechanisms. The newly generated B cells probably undergo selection processes that involve foreign and self-antigens and superantigens. We find preferential expansion and survival of B cells in normal and V-H-mutant ali/ali rabbits based on their heavy chain FR1 and FR3 sequences (V(H)a allotype). This selection may involve "superantigen"-like interactions with endogenous as well as exogenous ligands. (C) 1998 Academic Press.
