EFFECT OF STEROIDS ON CYCLING OF HAEMOPOIETIC STEM CELLS
EFFECT OF STEROIDS ON CYCLING OF HAEMOPOIETIC STEM CELLS
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DOI：
10.1038/2281204a0
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发表时间：
1970-01-01
期刊：
影响因子：
64.8
通讯作者：
BYRON, JW
中科院分区：
文献类型：
--
作者：
BYRON, JW
本报告描述了单剂量类固醇对造血干细胞细胞周期的影响（以前未报道）。这种增加脾脏集落形成单位（CFU）对3h -胸腺嘧啶致死性影响的敏感性的作用，早在类固醇对红细胞生成的长期影响之前就被发现了。在类固醇治疗的红细胞增多症小鼠中也观察到CFU对3h -胸苷的敏感性增加。后者的发现表明类固醇的作用不是通过促红细胞生成素介导的。
THIS report describes an effect (not previously reported) of single doses of steroids on the cell cycle of haemopoietic stem, cells. This effect, one of increasing the sensitivity of spleen colony forming units (CFU) to the lethal effects of3H-thymidine, is seen well before the long-term effects of steroids on erythropoiesis1. Increased sensitivity of CFU to3H-thymidine was also observed in steroid-treated polycythaemic mice. The latter finding suggests that the steroid effect is not mediated through erythropoietin.